A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders
dc.contributor.author | Rayner, C | |
dc.contributor.author | Coleman, JRI | |
dc.contributor.author | Purves, KL | |
dc.contributor.author | Hodsoll, J | |
dc.contributor.author | Goldsmith, K | |
dc.contributor.author | Alpers, GW | |
dc.contributor.author | Andersson, E | |
dc.contributor.author | Arolt, V | |
dc.contributor.author | Boberg, J | |
dc.contributor.author | Bogels, S | |
dc.contributor.author | Creswell, C | |
dc.contributor.author | Cooper, P | |
dc.contributor.author | Curtis, C | |
dc.contributor.author | Deckert, J | |
dc.contributor.author | Domschke, K | |
dc.contributor.author | El Alaoui, S | |
dc.contributor.author | Fehm, L | |
dc.contributor.author | Fydrich, T | |
dc.contributor.author | Gerlach, AL | |
dc.contributor.author | Grocholewski, A | |
dc.contributor.author | Hahlweg, K | |
dc.contributor.author | Hamm, A | |
dc.contributor.author | Hedman, E | |
dc.contributor.author | Heiervang, ER | |
dc.contributor.author | Hudson, JL | |
dc.contributor.author | Joehren, P | |
dc.contributor.author | Keers, R | |
dc.contributor.author | Kircher, T | |
dc.contributor.author | Lang, T | |
dc.contributor.author | Lavebratt, C | |
dc.contributor.author | Lee, S-H | |
dc.contributor.author | Lester, KJ | |
dc.contributor.author | Lindefors, N | |
dc.contributor.author | Margraf, J | |
dc.contributor.author | Nauta, M | |
dc.contributor.author | Pane-Farre, CA | |
dc.contributor.author | Pauli, P | |
dc.contributor.author | Rapee, RM | |
dc.contributor.author | Reif, A | |
dc.contributor.author | Rief, W | |
dc.contributor.author | Roberts, S | |
dc.contributor.author | Schalling, M | |
dc.contributor.author | Schneider, S | |
dc.contributor.author | Silverman, WK | |
dc.contributor.author | Stroehle, A | |
dc.contributor.author | Teismann, T | |
dc.contributor.author | Thastum, M | |
dc.contributor.author | Wannemueller, A | |
dc.contributor.author | Weber, H | |
dc.contributor.author | Wittchen, H-U | |
dc.contributor.author | Wolf, C | |
dc.contributor.author | Ruck, C | |
dc.contributor.author | Breen, G | |
dc.contributor.author | Eley, TC | |
dc.date.accessioned | 2020-04-22T09:36:29Z | |
dc.date.available | 2019-03-23 | |
dc.date.available | 2020-04-22T09:36:29Z | |
dc.date.issued | 2019-05-23 | |
dc.identifier.citation | Rayner, Christopher et al. "A Genome-Wide Association Meta-Analysis Of Prognostic Outcomes Following Cognitive Behavioural Therapy In Individuals With Anxiety And Depressive Disorders". Translational Psychiatry, vol 9, no. 1, 2019. Springer Science And Business Media LLC, doi:10.1038/s41398-019-0481-y. Accessed 22 Apr 2020. | en_US |
dc.identifier.issn | 2158-3188 | |
dc.identifier.other | ARTN 150 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/63680 | |
dc.description.abstract | Major depressive disorder and the anxiety disorders are highly prevalent, disabling and moderately heritable. Depression and anxiety are also highly comorbid and have a strong genetic correlation (rg ≈ 1). Cognitive behavioural therapy is a leading evidence-based treatment but has variable outcomes. Currently, there are no strong predictors of outcome. Therapygenetics research aims to identify genetic predictors of prognosis following therapy. We performed genome-wide association meta-analyses of symptoms following cognitive behavioural therapy in adults with anxiety disorders (n = 972), adults with major depressive disorder (n = 832) and children with anxiety disorders (n = 920; meta-analysis n = 2724). We estimated the variance in therapy outcomes that could be explained by common genetic variants (h2SNP) and polygenic scoring was used to examine genetic associations between therapy outcomes and psychopathology, personality and learning. No single nucleotide polymorphisms were strongly associated with treatment outcomes. No significant estimate of h2SNP could be obtained, suggesting the heritability of therapy outcome is smaller than our analysis was powered to detect. Polygenic scoring failed to detect genetic overlap between therapy outcome and psychopathology, personality or learning. This study is the largest therapygenetics study to date. Results are consistent with previous, similarly powered genome-wide association studies of complex traits. | en_US |
dc.publisher | Nature | en_US |
dc.relation.ispartof | TRANSLATIONAL PSYCHIATRY | |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.title | A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders | en_US |
dc.type | Article | en_US |
dc.rights.holder | © The Author(s) 2019 | |
dc.identifier.doi | 10.1038/s41398-019-0481-y | |
pubs.author-url | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000470933000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 9 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
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