Institute Director's Office: Recent submissions
Now showing items 1-20 of 117
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Novel class of photochromic molecules exhibiting photo-switching in the solid state.
(2023)Photo-switching compounds are widely used as super-resolution imaging agents, anti-counterfeiting dyes, and molecules that are able to control drug-receptor interactions. However, advancement of this field has been limited ... -
Rapid detection of major Gram-positive pathogens in ocular specimens using a novel fluorescent vancomycin-based probe
(2022-09-01)Bacterial infections of the eye are significant causes of morbidity that can lead to permanent visual loss without rapid and adequate treatment, with Gram-positive bacteria causing the majority of ocular infections. Here ... -
Synthesis of a water-soluble protoporphyrin polymer and its research on photodynamic inactivation of drug-resistant bacteria and cancer cells
(2022-12-30)Protoporphyrin IX (PPIX) is a photosensitizer in the photodynamic therapy. However, its aqueous insolubility is always a challenge for extensive applications. In this work, a water-soluble derivative of PPIX were synthesized ... -
Mechanisms Related to Inhibition of Fungal Biofilm Formation on Medical Device Coated with Poly(Methylmethacrylate-co-Dimethylacrylamide)
(2023-01-01)Candida albicans (C. albicans) are the most common cause of urinary fungal infections. C. albicans biofilms are of increasing clinical importance due to their resistance to antifungal therapy. Since the use of medical ... -
Synthesis of water-soluble protoporphyrin IX polymers and their photodynamic application
(2023-02-15)Protoporphyrin IX (PpIX) is a photosensitizer used in photodynamic therapy, however, its poor aqueous solubility always presents challenges and limits its application. To solve these problems water-soluble derivatives of ... -
A signal amplification for Trp isomers electrochemical recognition based on PEDOT:PSS and CS/PAA multilayers.
(2023-12-01)In this work, enhanced tryptophan (Trp) isomers recognition was successfully demonstrated on (CS/PAA)3.5@PEDOT:PSS/GCE, a multilayer chiral sensor with good stability and reproducibility. The (CS/PAA)n multilayers chiral ... -
pH-Activated Dissolvable Polymeric Coatings to Reduce Biofouling on Electrochemical Sensors.
(2023-06-20)Implantable electrochemical sensors that enable the real-time detection of significant biomarkers offer huge potential for the enhancement and personalisation of therapies; however, biofouling is a key challenge encountered ... -
Approved and investigational fluorescent optical imaging agents for disease detection in surgery.
(2023-08-01)Fluorescent optical imaging is becoming an increasingly attractive imaging tool that physicians can utilise as it can detect previously 'unseen' changes in tissue at a cellular level that are consistent with disease. This ... -
Development of biodegradable nanogels for lipase accelerated drug release of 5-aminolevulinic acid.
(2023-05)Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is an important approach for the treatment of some skin diseases and cancers. A major defect of this approach is that it is difficult for 5-ALA to accumulate ... -
Construction of CS/BSA multilayers for electrochemical recognition of tryptophan enantiomers
(2022-10-15)Ultra stable and reproducible electrochemical chiral interface ((CS/BSA)1.5/GCE) based on chitosan (CS) and bovine serum albumin (BSA) was fabricated using layer-by-layer (LbL) self-assembly technique. Its structure and ... -
Synthesis and Synergistic Antibacterial Activity of Cationic Polymer Fluorescent Nanoparticles Loaded with Fluorescent Conjugated Polymer
(2023-07-25)As drug-resistant bacteria infection become increasingly serious recently,pursuing new antibacterial strategies and developing more effective antibacterial materials have become an important task. This work provided a new ... -
Identifying Novel Biomarkers Ready for Evaluation in Low-Prevalence Populations for the Early Detection of Lower Gastrointestinal Cancers: A Systematic Review and Meta-Analysis.
(2021-06)INTRODUCTION: Lower gastrointestinal (GI) cancers are a major cause of cancer deaths worldwide. Prognosis improves with earlier diagnosis, and non-invasive biomarkers have the potential to aid with early detection. Substantial ...