dc.contributor.author | Jacobs, BM | en_US |
dc.contributor.author | Noyce, AJ | en_US |
dc.contributor.author | Giovannoni, G | en_US |
dc.contributor.author | Dobson, R | en_US |
dc.date.accessioned | 2020-02-11T15:02:51Z | |
dc.date.available | 2019-11-18 | en_US |
dc.date.issued | 2020-03 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/62737 | |
dc.description.abstract | OBJECTIVE: To update the causal estimates for the effects of adult body mass index (BMI), childhood BMI, and vitamin D status on multiple sclerosis (MS) risk. METHODS: We used 2-sample Mendelian randomization to determine causal estimates. Summary statistics for SNP associations with traits of interest were obtained from the relevant consortia. Primary analyses consisted of random-effects inverse-variance-weighted meta-analysis, followed by secondary sensitivity analyses. RESULTS: Genetically determined increased childhood BMI (ORMS 1.24, 95% CI 1.05-1.45, p = 0.011) and adult BMI (ORMS 1.14, 95% CI 1.01-1.30, p = 0.042) were associated with increased MS risk. The effect of genetically determined adult BMI on MS risk lessened after exclusion of 16 variants associated with childhood BMI (ORMS 1.11, 95% CI 0.97-1.28, p = 0.121). Correcting for effects of serum vitamin D in a multivariate analysis did not alter the direction or significance of these estimates. Each genetically determined unit increase in the natural-log-transformed vitamin D level was associated with a 43% decrease in the odds of MS (OR 0.57, 95% CI 0.41-0.81, p = 0.001). CONCLUSIONS: We provide novel evidence that BMI before the age of 10 is an independent causal risk factor for MS and strengthen evidence for the causal role of vitamin D in the pathogenesis of MS. | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Neurol Neuroimmunol Neuroinflamm | en_US |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | BMI and low vitamin D are causal factors for multiple sclerosis: A Mendelian Randomization study. | en_US |
dc.type | Article | |
dc.rights.holder | © 2020 The Author(s). | |
dc.identifier.doi | 10.1212/NXI.0000000000000662 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/31937597 | en_US |
pubs.issue | 2 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 7 | en_US |
dcterms.dateAccepted | 2019-11-26 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |