Methodological decisions influence the identification of potential core outcomes in studies related to pre-eclampsia: an analysis informing the development of recommendations for future core outcome set developers.
dc.contributor.author | Duffy, J | en_US |
dc.contributor.author | Hirsch, M | en_US |
dc.contributor.author | Ziebland, S | en_US |
dc.contributor.author | McManus, RJ | en_US |
dc.contributor.author | International Collaboration to Harmonise Outcomes in Pre-eclampsia (iHOPE) | en_US |
dc.date.accessioned | 2019-10-01T14:46:53Z | |
dc.date.available | 2019-07-12 | en_US |
dc.date.issued | 2019-11 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/59920 | |
dc.description.abstract | OBJECTIVE: To quantify the effect of different methodological decisions on the identification of potential core outcomes to inform the development of recommendations for future core coutcome set developers. DESIGN: Mixed methods study. SETTING: A core outcome set for pre-eclampsia was used as an exemplar. SAMPLE: A long list of potential core outcomes was developed by undertaking a systematic review of pre-eclampsia trials and performing a thematic analysis of in-depth patient interviews. METHODS: Specific methods used to generate long lists of potential core outcomes were evaluated. RESULTS: Different methodological decisions had a substantial impact on the identification of potential core outcomes. Extracting outcomes from published pre-eclampsia trials was an effective way of identifying 48 maternal, eight fetal, 25 neonatal outcomes, and eight patient-reported outcomes. Limiting the extraction of outcomes to primary outcomes or outcomes commonly reported in pre-eclampsia trials reduced the number and diversity of potential core outcomes identified. Thematic analysis of in-depth patient interviews ensured an additional five patient reported outcomes and six outcomes related to future child health were identified. CONCLUSIONS: Future core outcome set developers should use quantitative and qualitative methods when developing a long list of potential core outcomes. TWEETABLE ABSTRACT: @OfficialNIHR research published in @BJOGtweets informs new recommendations for future @coreoutcomes developers. | en_US |
dc.format.extent | 1482 - 1490 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | BJOG | en_US |
dc.subject | Core outcome sets | en_US |
dc.subject | outcomes | en_US |
dc.subject | pre-eclampsia | en_US |
dc.subject | qualitative interviews | en_US |
dc.subject | systematic review | en_US |
dc.subject | Decision Support Techniques | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Outcome Assessment, Health Care | en_US |
dc.subject | Pre-Eclampsia | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Prenatal Diagnosis | en_US |
dc.title | Methodological decisions influence the identification of potential core outcomes in studies related to pre-eclampsia: an analysis informing the development of recommendations for future core outcome set developers. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1111/1471-0528.15892 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/31359560 | en_US |
pubs.issue | 12 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 126 | en_US |
dcterms.dateAccepted | 2019-07-12 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |