Vitamin D for the management of chronic obstructive pulmonary disease

Abstract

Copyright © 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. is is a protocol for a Cochrane Review (Intervention). The objectives are as follows: Our primary objectives are to determine whether Vitamin D supplementation reduces the risk of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) requiring systemic corticosteroids, antibiotics or both. Our secondary objectives are to evaluate the impact of Vitamin D supplementation on other effectiveness outcomes, including severe AECOPD, i.e. Those requiring emergency department (ED) attendance or hospitalisation, moderate AECOPD, study-defined AECOPD, adverse events, death, symptom control, industrial absenteeism, self-reported short-acting bronchodilator use, quality of life; physiological and biochemical, including lung function, exercise tolerance, muscle strength, biomarkers of inflammation, costeffectiveness and safety in people with COPD.