dc.contributor.author | Panter-Brick, C | |
dc.contributor.author | Wiley, K | |
dc.contributor.author | Sancilio, A | |
dc.contributor.author | Dajani, R | |
dc.contributor.author | Hadfield, K | |
dc.date.accessioned | 2019-04-18T09:36:58Z | |
dc.date.available | 2019-02-14 | |
dc.date.available | 2019-04-18T09:36:58Z | |
dc.date.issued | 2019-02-20 | |
dc.identifier.citation | Panter-Brick, C., Wiley, K., Sancilio, A., Dajani, R. and Hadfield, K. (2019). C-reactive protein, Epstein-Barr virus, and cortisol trajectories in refugee and non-refugee youth: Links with stress, mental health, and cognitive function during a randomized controlled trial. Brain, Behavior, and Immunity. [online] Available at: https://www.sciencedirect.com/science/article/pii/S0889159118303416?via%3Dihub [Accessed 19 Mar. 2019]. | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/56910 | |
dc.description.abstract | Experiencing childhood adversity has been associated with significant changes in inflammation, cell-mediated immunocompetence, and cortisol secretion. Relatively few studies have examined, longitudinally, alterations to inflammatory processes during adolescence, especially outside Western contexts; none have evaluated biomarker trajectories for at-risk youth in response to a structured behavioral intervention. We conducted a randomized controlled trial evaluating the efficacy of a humanitarian intervention targeting stress-alleviation, with 12-18 year-old Syrian refugees (n = 446) and Jordanian non-refugees (n = 371) living side-by-side in war-affected communities in Jordan. We measured C-reactive protein (CRP), Epstein-Barr virus antibodies (EBV), and hair cortisol concentration (HCC) at three timepoints (pre/post intervention and 11 month follow-up), and assessed three main outcomes (psychosocial stress, mental health, and cognitive function). Using growth mixture models, regressions, and growth curve models, we identified three distinct trajectories for CRP, two for EBV, and three for HCC, and examined their associations with age, gender, BMI, poverty, and trauma. We found associations with BMI for CRP, refugee status for EBV, and BMI and gender with HCC trajectory. In terms of health outcomes, we found associations between rising CRP levels and perceived stress (B = -2.92, p = .007), and between HCC hypersecretion and insecurity (B = 7.21, p = .017). In terms of responses to the intervention, we observed no differential impacts by CRP or EBV trajectories, unlike HCC. These results suggest that commonly-assayed biomarkers do not associate with health outcomes and respond to targeted interventions in straightforward ways. Our study is the first to examine multiple biomarker trajectories in war-affected adolescents, in order to better evaluate the extent, timing, and malleability of the biological signatures of poverty, conflict, and forced displacement. | en_US |
dc.language | eng | |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Brain Behav Immun | |
dc.subject | Adolescent | en_US |
dc.subject | Cortisol | en_US |
dc.subject | Immune function | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Life history | en_US |
dc.subject | Mental health | en_US |
dc.subject | Randomized control trial | en_US |
dc.subject | Refugee | en_US |
dc.subject | Stress | en_US |
dc.subject | War | en_US |
dc.title | C-reactive protein, Epstein-Barr virus, and cortisol trajectories in refugee and non-refugee youth: Links with stress, mental health, and cognitive function during a randomized controlled trial. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2019 The Authors. | |
dc.rights.holder | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |
dc.identifier.doi | 10.1016/j.bbi.2019.02.015 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30797045 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
dcterms.dateAccepted | 2019-02-14 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |