Theses: Recent submissions
Now showing items 21-40 of 4248
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ELUCIDATING THE MOLECULAR MECHANISMS OF POSTNATAL GROWTH RESTRICTION USING NOVEL PATIENT GENETIC VARIANTS
Short stature remains one of the commonest presentations to paediatric endocrinologists. A subset of patients with short stature (height SDS ≤ -2) are diagnosed with growth hormone insensitivity (GHI). GHI is a spectrum ... -
The Nutritional Status of Behçet's Disease Patients
Introduction: Nutrition and immunity are closely related because the immune system's cells use the most energy. Behçet's disease (BD) presents with a diverse range of symptoms, such as ulcers in the mouth and genitals, eye ... -
Extended career-breaks and struggles returning to the workplace: insights from professional women in the United Kingdom
The prevalence of career-breaks amongst professional women, mainly due to childcare, is a widely acknowledged and researched area. Yet most of the research undertaken about the career-break and return experiences of ... -
Over-the-Air Federated Learning with Enhanced Privacy and Security
Federated learning (FL) is a promising paradigm in machine learning (ML) that addresses the challenges posed by centralised data storage and processing. However, deploying FL faces challenges such as resource limitations ... -
Investigating the influence of synovium on cartilage response to inflammatory stimuli using predictive in vitro models
Inflammatory joint diseases, such as rheumatoid arthritis and osteoarthritis, constitute a significant economic and social burden. Currently there are very few disease modifying treatments, the search for which is hampered ... -
Lifestyle and wealth as determinants of intestinal disease in a Zambian city: are environmental enteropathy and ulcerative colitis mutually exclusive?
Environmental enteropathy (EE) is an asymptomatic lesion of the small intestine which is likely to be an adaptive response to adverse environmental conditions, including frequent exposure to enteropathogens, leading to ... -
Leveraging Single Cell Multiomics to Dissect Longitudinal and Spatial Heterogeneity in Follicular Lymphoma
Follicular lymphoma (FL) exhibits substantial clinical heterogeneity, presenting a distinct challenge for the prognostication and treatment of patients. Transformation of FL to aggressive diffuse large B-cell lymphoma (tFL) ... -
Relativistic gravity in the inhomogeneous Universe
Cosmology is built on a relativistic understanding of gravity, where the geometry of the Universe is dynamically determined by matter and energy. In the cosmological concordance model, gravity is described by General ... -
Astrochemistry at Large Facilities: Formation of Methyl Formate and its isomers and the survivability of Ethanolamine in Astrophysical Relevant ices
Complex organic molecules (COMs) efficiently form within icy mantles on the surfaces of dust grains in the interstellar and circumstellar medium (ISM and CSM) through atom- or radical-addition chemistry or radiation ... -
IL10 signalling in human vascular development: human vascular cell differentiation from induced-pluripotent stem cells
Cardiovascular disease (CVD) remains the primary cause of mortality worldwide. Existing treatment strategies, focusing on behavioral modification, pharmaceutical interventions, and surgical procedures, largely aim to slow ... -
Digital Lifestyle Analysis in Disorders of Gut - Brain Interaction
In the U.K., 1 in 3 adults meet criteria for disorders of gut-brain interaction (DGBI) – a group of conditions classified by chronic gastrointestinal symptoms, for which there is no single cure. Despite their high prevalence ... -
Medicine and the Gentry Woman: Care and Wellbeing in Late Medieval English Households
Hundreds of recipe collections survive from late medieval England. This thesis focuses on six manuscripts, which contain primarily medical advice as well as general tips for hygiene and well-being in English. These manuscripts ... -
Centromeric Chromatin Assembly in Fission Yeast
Centromeres are specialised chromosome loci which play an important role in cell division because they serve as the sites of kinetochore assembly, and this ultimately enables chromosome segregation. Interestingly, the DNA ... -
BIOFABRICATION OF A SELF-ASSEMBLING MATRIX TO MODEL THE TUMOUR MICROENVIRONMENT OF OVARIAN CANCER
Self-assembled systems play an important role in biomedical research due to the advantages they provide, such as the ability to mimic the structure of the extracellular matrix (ECM), tunable mechanical properties, and ... -
Semantic Communications for Speech Transmission
Wireless communication systems have undergone vigorous advancements from the first generation (1G) to the fifth generation (5G) over the past few decades by developing numerous coding algorithms and channel models to recover ... -
Childhoods under Military Occupation: everyday experiences, resistance and citizenship for children and young people in Kashmir
This thesis addresses the everyday experiences of violence and militarization of children and young people living under the Indian occupation of Kashmir. The research builds on the conceptualization of childhood as a site ... -
Embodied Protest
(2024-07-08)This thesis examines the deployment of performance art during protests in contemporary Chile. I analyse examples of performance art, or locally defined art actions, and ask how they can be considered embodied dissent, ... -
Artistic and Photorealistic image style transfer using deep learning
Style transfer is a popular technique in computer vision and image processing that involves generating an image that combines the content of one image with the style of another image or of a collection of images. In this ... -
Tackling Sexist Hate Speech: Cross-Lingual Detection and Multilingual Insights from Social Media
With the widespread use of social media, the proliferation of online communication presents both opportunities and challenges for fostering a respectful and inclusive digital environment. Due to the anonymity and weak ... -
Data in Policing: An Examination of the Behavioural Responses of Public Officials
Data-driven and algorithmic technologies are ambitiously implemented in the public sector to improve operational efficiency and decision-making. Researchers have assessed the impact of these technologies mainly from a ...