Browsing Theses by Subject "syntehtic lethality"
Now showing items 1-2 of 2
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Human mononuclear phagocytes and their control by IL-10 in health and inflammatory bowel disease
(Queen Mary University of London, 05/11/2019)Intestinal macrophages, derived in part from monocytic precursors, are critical targets of IL-10, which prevents the development of colitis in mice. In humans, loss-of-function IL-10R mutations cause early-onset inflammatory ... -
Investigations of LIMD1 in miRNA-mediated gene silencing and cancers
(Queen Mary University of London, 2018-05-08)In recent years, LIM domains-containing protein 1 (LIMD1) has been identified as a critical component in microRNA (miRNA)-induced silencing complex (miRISC) to regulate miRNA-mediated gene silencing. Human Argonaute (AGO) ...