Browsing Theses by Subject "Cancer"
Now showing items 1-20 of 42
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Bayesian Networks for Evidence Based Clinical Decision Support.
(Queen Mary University of London, 2013)Evidence based medicine (EBM) is defined as the use of best available evidence for decision making, and it has been the predominant paradigm in clinical decision making for the last 20 years. EBM requires evidence from ... -
Celebrity privacy and the development of the judicial concept of proportionality: How English law has balanced the rights to protection and interference
(Queen Mary University of London, 10/11/2014)This thesis examines how English law has, and has not, balanced celebrities’ legal expectations of informational and seclusional privacy against the press and media’s rights to inform and publish. Much of the litigation ... -
Cellular and Molecular Signature of Oral Squamous Cell Carcinoma
(Queen Mary University of London, 2018-05-09)Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide. It is a result of numerous aetiological factors such as genetic predisposition, smoking, excessive alcohol consumption and viruses such as the ... -
Counsel and Command in Anglophone Political Thought, 1485-1651
(Queen Mary University of London, 2013)This thesis investigates the role and vocabulary of ‘political counsel’ in Anglophone discourse from the end of the Wars of the Roses (1485) to the end of the English Civil War (1651), demonstrating its importance as a ... -
Delineating a Functional Role for the Urinary Biomarker Lipocalin 2 in Prostate Cancer
(Queen Mary University of London, 2014-09-18)Prostate cancer (PCa) is the most commonly diagnosed cancer amongst Western males. PCa progression is strongly linked to steroid receptor signalling, however the modulation of steroid receptor expression in PCa is incompletely ... -
Desmoplastic stromal cells modulate tumour cell behaviour in pancreatic cancer
(Queen Mary University of London, 2013-01)Pancreatic ductal adenocarcinoma (PDAC) is characterised by an intense desmoplastic stromal response that can comprise 60 to 80% of tumour volume and has been implicated to be a factor in pr ... -
The Development and Characterisation of Peptides to Image αvβ6 in Cancer.
(Queen Mary University of London, 2011-01)Introduction The epithelial-specific integrin αvβ6 usually is undetectable on normal, adult, human tissue but is upregulated during tissue re-modelling and carcinogenesis. Objective To develop and characterise agents for ... -
Development of New Methods to Support Systemic Incident Analysis.
(Queen Mary University of London, 11/11/2015)Explaining incidents as systems is a fast growing area of safety scientific research. The misleading conception of naturalistic human communication in terms of ‘objective information’ remains a pervasive influence on ... -
Endothelial specific inactivation of FAK-Y397 and FAK-Y861 phosphorylation in tumour growth and angiogenesis in vivo
(Queen Mary University of London, 2017-03-28)Tumour angiogenesis is a hallmark of cancer. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase involved in endothelial cells (ECs) survival, proliferation and migration. FAK has several tyrosine phosphoryla ... -
Epithelial cell adaptation to supernumerary centrosomes
(Queen Mary University of London, 2017-10-26)The centrosome is the main microtubule-organising centre in animal cells; important to assemble a bipolar mitotic spindle ensuring proper chromosome segregation and genomic stability. Whereas correct centrosome number ... -
EXPERIENCING ‘HOME’ IN THE CITY, UNIVERSITY, AND DWELLING: EVERYDAY GEOGRAPHIES OF INDIAN STUDENTS IN LONDON AND TORONTO.
(Queen Mary University of London, 08/11/2015)The global mobility of international students has a distinct geography. For international students, moving from their 'home' countries to a new country entails significant changes in their everyday lives. Moving across ... -
Ferromagnetically filled carbon nanotubes: Radial structures and tuning of magnetic properties through new synthesis methods.
(Queen Mary University of London, 2013)Multiwall carbon nanotubes filled with continuous single-crystals of the ferromagnetic phase -Fe were produced with two new synthesis methods: the boundary layer chemical vapour synthesis and the perturbed vapour chemical ... -
The genetic and functional basis of three inherited cutaneous and gastrointestinal diseases in humans
(Queen Mary University of London, 29/05/2014)This thesis describes investigations into the genetic basis and pathophysiology of three distinct inherited diseases in humans, two of which are strongly associated to the function of the ectodomain sheddase enzyme ADAM17. The ... -
The Genetic Status of the PIK3CA Oncogene and Activity of the PI3K-AKTmTOR Pathway in Penile Squamous Cell Carcinoma
(Queen Mary University of London, 2017-03-15)Penile squamous cell carcinoma (PSCC) is rare; hence little is known about its aetiology and pathogenesis. Two challenges exist in the clinical management of PSCC patients. Firstly, finding a non-invasive method to aid the ... -
Gold-Mediated C–H Functionalisation
(Queen Mary University of London, 2013)The transition metal–catalysed direct functionalisation of C–H bonds is an increasingly viable alternative to the multi–step strategies traditionally employed. The use of powerful and environmentally benign gold species ... -
Identification of novel therapeutics for the treatment of MMR deficient tumours using high-throughput screens.
(Queen Mary University of London, 2015-05)The DNA Mismatch repair (MMR) pathway is responsible for the repair of base-base mismatches and insertion/deletion loops, formed during DNA replication. Mutations in MMR genes significantly increase the predisposition to ... -
Investigating Clustering in Trisomy 18 and Trisomy 13
(Queen Mary University of London, 01/07/2014)Trisomies 18 and 13 are rare genetic conditions (occurring around 1 in 6,000 and 10,000 newborns respectively) which are caused by an extra copy of either chromosome 18 or 13, similar to trisomy 21 (Down syndrome). The ... -
Investigating the functional significance of an FGFR2 intronic SNP in Breast Cancer
(Queen Mary University of London, 2013-05)Single nucleotide polymorphisms present in the second intron of the fibroblast growth factor receptor 2 (FGFR2) gene have been linked with increased risk of breast cancer in several genome wide association studies. The ... -
Investigations into effects of 12-lipoxygenase and NADPH oxidase on platelet activity, and influences of dietary dark chocolate
(Queen Mary University of London, 2012)Platelets play a pivotal role in both normal hemostasis and pathological bleeding and importantly also contribute to the development of atherothrombosis. Even though platelet function tests traditionally are utilised mainly ... -
Light-addressable potentiometric sensors based on self-assembled organic monolayer modified silicon on sapphire substrates
(Queen Mary University of London, 13/11/2015)Light-addressable potentiometric sensors (LAPS) have become attractive in many chemical and biological sensor applications. This thesis introduces the use of self-assembled organic monolayers (SAMs) as the insulator in ...