Browsing Theses by Author "dos Santos Soares Martins de Castro, Alicia Maria"
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A mechanistic investigation into candidate markers of telomere-induced senescence in normal human epidermal keratinocytes
dos Santos Soares Martins de Castro, Alicia Maria (Queen Mary University of London, 2014-02-02)Telomere dysfunction is one mechanism of cellular and tissue ageing. Dysfunctional telomeres in fibroblasts are recognised as DNA double-strand breaks (DSBs) and trigger the DNA damage pathway of senescence. However, telomere ...