Browsing Theses by Title
Now showing items 1801-1820 of 4235
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I Know Something You Don’t Know: Contemporary Performance and the Politics of Expertise
(Queen Mary University of London, 2012-07)This thesis explores the figure of the expert in a range of contemporary performance practices. Much has been written in recent years about the rise of education, pedagogy and research as both curatorial strategies and ... -
IDENTIFICATION AND ANALYSIS OF DRUG-IMPREGNATED PAPER FROM PRISONS IN ENGLAND BETWEEN 2018-2020
(2022)Introduction: Drug misuse is a global concern that has become increasingly widespread across all levels of society. Its use in prisons contributes to greater disruption and violence, as well as having a negative influence ... -
Identification and characterisation of endogenous inducible promoters in Mycobacterium tuberculosis
(Queen Mary University of London, 2010)Mycobacterium tuberculosis is one of the world’s most devastating pathogens. Despite completion of the genome sequence in 1998, research progress has been hampered by a lack of genetic tools and the difficulty of working ... -
Identification and characterisation of mucin abnormalities in the ganglionic bowel in Hirschsprung's disease
(Queen Mary University of London, 2010)Hirschsprung’s disease (HD) is a congenital abnormality of unknown origin, characterised by a lack of ganglion cells in the distal colon which results in functional colonic obstruction. The major cause of morbidity and ... -
Identification and characterisation of novel genetic mutations in familial and sporadic neuroendocrine tumours of the endocrine pancreas, thyroid and pituitary gland
(2023)A variable proportion of neuroendocrine tumours arise in the setting of familial tumour-predisposing conditions as a result of a genetic mutation. Owing to de novo mutations or incomplete penetrance, predisposing mutations ... -
Identification and functional characterization of relaxin-type and pedal peptide/orcokinin-type neuropeptides in the starfish Asterias rubens
(Queen Mary University of London, 2017-09-27)Neuropeptides are neuronal signaling molecules that regulate many physiological and behavioural processes in vertebrates and invertebrates. Investigation of neuropeptide signaling in echinoderms (e.g. starfish) can provide ... -
The identification and interpretation of pathogenic non-coding mutations in pancreatic ductal adenocarcinoma.
(Queen Mary University of London., 2021-07-26)Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Despite significant advances in medicine and surgery, pancreatic cancer still has a dismal 5-year survival rate below ... -
Identification and Prioritisation of Cardiovascular Disease Genes
Coronary Artery Disease (CAD) is known to be highly prevalent in individuals from South Asian (SA) heritage such as Pakistanis and Bangladeshis [1, 2]. However, conclusive causal inference explaining this increased risk ... -
Identification of adenovirus E1A gene regions involved in chemosensitisation of prostate cancer cells
(2009)Replication-selective adenoviruses are promising anti-cancer therapies (virotherapy). Viruses can be engineered to selectively target cancer cells by deleting viral genes involved in cell cycle regulation. These deletions ... -
Identification of disease gene variants that can lead to familial myelodysplasia and acute myeloid leukaemia
(Queen Mary University of London, 2018-05-05)Myelodysplasia (MDS) is characterised by inefficient haematopoiesis with dysplastic features of blood and bone marrow, reduction of mature blood cells and continuous bone marrow failure (BMF). Acute myeloid leukaemia ... -
Identification of DLK1-positive cell clusters in the human adrenal cortex and their potential involvement in adrenocortical carcinoma.
(Queen Mary University of London, 28/03/2019)The adrenal glands are vital endocrine organs responsible for the synthesis and secretion of multiple steroids and hormones. They are composed of an inner adrenal medulla and an outer adrenal cortex. The human adrenal ... -
Identification of DNA mismatch repair molecular signatures that predict response to immune checkpoint blockade.
(Queen Mary University of London, 2021-07-25)Despite showing great clinical promise, response rates to immune checkpoint blockade (ICB) vary greatly and biomarkers of response are lacking. A recent Phase II clinical trial in patients with deficiency in the DNA ... -
Identification of genetic factors involved in morphoeic basal cell and sebaceous gland carcinoma of human eyelid tumours with a view to identifying potential treatment targets
(Queen Mary University of London, 2017-07-17)Periocular malignancy represents an increasing burden and currently requires disfiguring surgery in an attempt to cure patients. Basal cell carcinoma (BCC) is the commonest cancer worldwide and morphoeic BCC (mBCC) is an ... -
Identification of HETE isoforms produced by activated platelets and study of their roles within the vasculature.
(Queen Mary University of London, 17/04/2015)Background: Prostaglandins (PGs) and hydroxyeicosatetraeinoic acids (HETEs) are synthesized from arachidonic acid (AA) released from the membrane phospholipids of cells through the activity of cytosolic phospholipase A2α ... -
IDENTIFICATION OF NONLINEAR DYNAMIC SYSTEMS USING THE FORCE-STATE MAPPING TECHNIQUE
(Queen Mary University of London, 1989)The identification of the dynamic characteristics of nonlinear systems is of increasing interest in the field of modal testing. In this work an investigation has been carried out into the force-state mapping approach ... -
Identification Of Novel Mechanisms Of Glucolipotoxicity In Type 2 Diabetes.
(Queen Mary University of London, 2015-01)Type 2 Diabetes, a metabolic disorder associated with chronic hyperglycaemia and hyperlipidaemia, is characterised by an impairment of insulin secretion and production and β-cell death. This β-cell dysfunction is determined ... -
Identification of novel regulators of HIFs for use in anti-cancer target development
(Queen Mary University of London, 27/09/2018)Solid tumours display vast heterogeneity in oxygen tension as a consequence of poor vascularization and increased proliferation. Tumour hypoxia (low oxygen) is associated with poor prognosis as cells within this harsh ... -
Identification of Novel Targetable Signaling Pathways in the Inherited Ichthyoses
(2017-01-11)In this study the non-syndromic ichthyoses were studied to evaluate any genes or biological processes common to them and to identify key genes and pathways pertaining to each ichthyosis individually. This group of monogenic ... -
Identification of novel therapeutics for the treatment of MMR deficient tumours using high-throughput screens.
(Queen Mary University of London, 2015-05)The DNA Mismatch repair (MMR) pathway is responsible for the repair of base-base mismatches and insertion/deletion loops, formed during DNA replication. Mutations in MMR genes significantly increase the predisposition to ... -
Identification of the genetic alterations in prostate cancer metastases
(Queen Mary University of London, 2017-01-11)Prostate cancer (PCa) is the most common cancer among men in Western developed countries. While the majority of PCa diagnosed by PSA screening are indolent, advanced and metastatic disease has a significant mortality and ...