Browsing Theses by Title
Now showing items 3446-3465 of 4235
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The role of ryanodine receptors in development
(Queen Mary University of London, 2011)Calcium ions (Ca2+) are fundamental to the regulation of many cellular processes; however, the coordination of these signals during embryogenesis is not well understood. Ryanodine receptors (RyR) are a family of important ... -
The role of sexual selection in adaptation to novel environments and the effects of environmental change on sexual selection
(Queen Mary University of London, 2018-05-01)Sexual selection is ubiquitous in all sexually reproducing species and a powerful evolutionary force. The effect of sexual selection on population fitness has caused wide debate and has been proposed to both enhance ... -
The Role of Skills Use, Common and Extratherapeutic Factors in Dialectical Behaviour Therapy for Borderline Personality Disorder
(Queen Mary University of London, 2013)This thesis investigates the role of specific, common and extratherapeutic factors in dialectical behaviour therapy (DBT) for borderline personality disorder (BPD) with self-harm, using both quantitative and qualitative ... -
The role of small extracellular vesicles secreted by cells with centrosome amplification in shaping the Pancreatic Ductal Adenocarcinoma Microenvironment
(2022)Centrosome amplification is associated with worse cancer prognosis, and it was found to induce spontaneous tumorigenesis and invasion contributing to malignant progression. Pancreatic Ductal Adenocarcinoma (PDAC) tumours ... -
The role of soluble FMS-like tyrosine kinase (sFLT1) and FAS associated proteins in pregnancies complicated by preeclampsia and intrauterine growth restriction (IUGR).
(2005)Current thinking suggests that preeclampsia is associated with activation of the maternal vascular endothelium in response to factors released from the placenta due to placental hypoxia. Failure of physiological modification ... -
The role of tax incentives in a trio of Sub-Saharan African economies : a comparative study of Nigerian, South African and Kenyan tax law.
(2008)This Thesis evaluates the role of tax incentives in promoting sustainable economic development in developing countries, comparing the South African and Kenyan experiences with that of Nigeria, with a view to suggesting ... -
The role of the aryl hydrocarbon receptor (AHR) in immune regulation in the human intestine
(Queen Mary University of London, 2021)Environmental factors play a major role in the development of inflammatory bowel disease (IBD). However, current understanding about how environmental factors influence disease is limited and there is a major unmet need ... -
The role of the aryl hydrocarbon receptor interacting protein (AIP) in pituitary tumorigenesis: A novel animal model for investigating the role of AIP during embryogenesis and pituitary tumour formation
(2023)Pituitary adenomas (PAs) have a 1:1000 prevalence and carry significant morbidity despite their benign nature. Mutations in the AIP (aryl hydrocarbon receptor interacting protein) gene have been unambiguously associated ... -
The role of the aryl hydrocarbon receptor interacting protein (AIP) in pituitary tumorigenesis: A proteomic approach for explaining the clinical behaviour of AIP mutation-associated pituitary adenomas
(Queen Mary University of London, 2015-09-04)A subset of familial and sporadic pituitary adenomas is due to germline mutations in the aryl hydrocarbon receptor interacting protein gene (AIP). A systematic follow-up of cases and families with AIP mutation ... -
The role of the cell attachment in the regulation of telomerase during keratinocyte differentiation
(Queen Mary University of London, 2010)The catalytic subunit of telomerase TERT has non-canonical functions, which are independent of telomere elongation and sometimes telomerase activity. In skin keratinocytes, both TERT expression and anoikis are regulated ... -
The role of the chemokine receptor CXCR4 in oral squamous cell carcinoma metastasis
(Queen Mary University of London, 2010)Oral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer worldwide. The greatest cause of mortality and surgical morbidity is due to the common spread of tumour cells from the primary lesion to the lymph nodes ... -
The Role of the Chief Justice in Commonwealth Africa: a comparative study of South Africa, Ghana and Kenya
(Queen Mary University of London, 2012)This is a comparative study of the leadership role of the Chief Justice as head of the judiciary through a decade of change, up to 2009, in South Africa, Ghana and Kenya. It draws on a ... -
THE ROLE OF THE DNA DAMAGE AND REPAIR PATHWAYS IN THE EFFICACY OF ONCOLYTIC ADENOVIRUS FOR OVARIAN CANCER
(Queen Mary University of London, 2016-06)Defects within the DNA damage response (DDR) pathways are common in human malignancies. This is especially true in high-grade serous ovarian cancer (HGSOC) where defects within the Homologous Recombination (HR) pathway ... -
The role of the Epstein Barr Virus in B cell tolerance loss in rheumatoid arthritis disease.
(Queen Mary University of London., 2021-02-08)Although many efforts have been done in understanding the aetiology of rheumatoid arthritis (RA), the Epstein-Barr Virus (EBV) remains one of the strongest candidates to be investigated as possible environmental factors ... -
The Role of the family in cases of disputed medical decision making
(2009)This doctoral thesis considers the family’s role in the process of making medical treatment decisions for one of its members. Chapter 1 explores the meaning of family in the context of illness and disability. It is ... -
The Role of the HUSH complex and LINE-1 elements in the Regulation of Type 1 Interferon
Although Transposable Elements (TEs) have been a reliable source of genetic variation throughout evolution (Rishishwar et al., 2018), host genomes have simultaneously coevolved with TEs to employ a variety of strategies ... -
Role of the inhibitory receptor LAIR-1 on NK cells in Chronic Hepatitis B
(Queen Mary University of London, 2018-08-03)There are multiple immune mechanisms identified for persistence of hepatitis B virus (HBV) infection. This thesis considers the vital role that inhibitory receptors play in contributing to impairment of the adaptive immune ... -
The role of the judge and jury in complex trials
(Queen Mary University of London, 2008)This thesis examines the mode of trial concerns in the U.S.A., New York State, California, England and Wales and Canada --specifically the ability of the jury to comprehend complex cases and the perception/reality that ... -
The role of the melanocortin receptors in adrenal growth, development and stem cell maintenance
(Queen Mary University of London, 2017-03-08)The adrenal gland is a highly dynamic organ with the ability to respond to changes in its environment with rapid changes in hormone production, and dramatic remodelling of its structure. Our understanding of the role of ... -
The role of the NK cell receptor CD160 in the diagnosis, differentiation and function of chronic B-cell malignancies.
(Queen Mary University of London, 2013-04-18)Chronic Lymphocytic Leukaemia (CLL) remains the most abundant leukaemia in those aged over 65 years. It is characterised by the expansion of malignant monoclonal B-lymphocytes that were originally described as being ...