Browsing Centre for Oral Immunobiology and Regenerative Medicine by Author "James, EL"
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The Extracellular Metabolome Stratifies Low and High Risk Potentially Premalignant Oral Keratinocytes and Identifies Citrate as a Potential Non-Invasive Marker of Tumour Progression.
Karen-Ng, LP; James, EL; Stephen, A; Bennett, MH; Mycielska, ME; Parkinson, EK (MDPI, 2021-08-21)Premalignant oral lesions (PPOLs) which bypass senescence (IPPOL) have a much greater probability of progressing to malignancy, but pre-cancerous fields also contain mortal PPOL keratinocytes (MPPOL) that possess ... -
Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism.
James, EL; Lane, JAE; Michalek, RD; Karoly, ED; Parkinson, EK (2016-12-07)Cellular senescence occurs by proliferative exhaustion (PEsen) or following multiple cellular stresses but had not previously been subject to detailed metabolomic analysis. Therefore, we compared PEsen fibroblasts with ... -
Serum metabolomics in animal models and human disease
James, EL; Parkinson, EK (2015-09)