Browsing Centre for Oral Immunobiology and Regenerative Medicine by Author "Huang, Y"
Now showing items 1-6 of 6
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The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53
Rehman, A; Cai, Y; Huenefeld, C; Jedlickova, H; Huang, Y; Teh, MT; Ahmad, US; Uttagomol, J; Wang, Y; Kang, A (Springer Nature, 2019-10-03)Desmoglein-3 (Dsg3), the Pemphigus Vulgaris (PV) antigen (PVA), plays an essential role in keratinocyte cell–cell adhesion and regulates various signaling pathways involved in the progression and metastasis of cancer where ... -
Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces
Uttagomol, J; Ahmad, US; Rehman, A; Huang, Y; Laly, AC; Kang, A; Soetaert, J; Chance, R; Teh, M-T; Connelly, JT (MDPI, 2019-12-10)Desmoglein 3 (Dsg3) plays a crucial role in cell-cell adhesion and tissue integrity. Increasing evidence suggests that Dsg3 acts as a regulator of cellular mechanotransduction, but little is known about its direct role in ... -
Evolving Mechanisms in the Pathophysiology of Pemphigus Vulgaris: A Review Emphasizing the Role of Desmoglein 3 in Regulating p53 and the Yes-Associated Protein.
Rehman, A; Huang, Y; Wan, H (2021-06-26)The immunobullous condition Pemphigus Vulgaris (PV) is caused by autoantibodies targeting the adhesion proteins of desmosomes, leading to blistering in the skin and mucosal membrane. There is still no cure to the disease ... -
Oxidative Stress-Mediated YAP Dysregulation Contributes to the Pathogenesis of Pemphigus Vulgaris
Huang, Y; Jedličková, H; Cai, Y; Rehman, A; Gammon, L; Ahmad, US; Uttagomol, J; Parkinson, EK; Fortune, F; Wan, H (Frontiers Media, 2021-04-19) -
Oxidative stress-mediated yes-associated protein dysregulation contributes to the pathogenesis of pemphigus vulgaris
Huang, Y; Jedlickova, H; Cai, Y; Rehman, A; Gammon, L; Ahmad, US; Uttagomol, J; Chance, R; Kang, A; Parkinson, EK (Frontiers Media, 2022-04-19)Pemphigus Vulgaris (PV) is a life-threatening autoimmune disease manifested with blisters in the skin and mucosa and caused by autoantibodies against adhesion protein desmoglein-3 (Dsg3) expressed in epithelial membrane ... -
YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions
Huang, Y; Ahmad, US; Rehman, A; Uttagomol, J; Wan, H (2022)