Browsing Biochemistry by Subject "Ubiquitin-Protein Ligases"

Now showing items 1-1 of 1

    • Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. 

      Shah, RR; De Vita, E; Sathyamurthi, PS; Conole, D; Zhang, X; Fellows, E; Dickinson, ER; Fleites, CM; Queisser, MA; Harling, JD (2024-03-28)
      Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that have emerged as a therapeutic modality to induce targeted protein degradation (TPD) by harnessing cellular proteolytic degradation machinery. ...