Browsing Biochemistry by Author "Viles, JH"
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Amyloid- oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy
Bode, DC; Freeley, M; Nield, J; Palma, M; Viles, JH (2019-05-10) -
Copper(II) Can Kinetically Trap Arctic and Italian Amyloid‑β40 as Toxic Oligomers, Mimicking Cu(II) Binding to Wild-Type Amyloid‑β42: Implications for Familial Alzheimer’s Disease
Tian, Y; Shang, Q; Liang, R; Viles, JH (American Chemical Society (ACS), 2024-02-06)The self-association of amyloid-β (Aβ) peptide into neurotoxic oligomers is believed to be central to Alzheimer’s disease (AD). Copper is known to impact Aβ assembly, while disrupted copper homeostasis impacts phenotype ... -
Impact of Membrane Phospholipids and Exosomes on the Kinetics of Amyloid-β Fibril Assembly.
Khursheed, A; Viles, JH (2024-03-15)Alzheimer's disease (AD) is linked with the self-association of the amyloid-β peptide (Aβ) into oligomers and fibrils. The brain is a lipid rich environment for Aβ to assemble, while the brain membrane composition varies ...