Browsing Biochemistry by Author "Tian, Y"
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Copper(II) Can Kinetically Trap Arctic and Italian Amyloid‑β40 as Toxic Oligomers, Mimicking Cu(II) Binding to Wild-Type Amyloid‑β42: Implications for Familial Alzheimer’s Disease
Tian, Y; Shang, Q; Liang, R; Viles, JH (American Chemical Society (ACS), 2024-02-06)The self-association of amyloid-β (Aβ) peptide into neurotoxic oligomers is believed to be central to Alzheimer’s disease (AD). Copper is known to impact Aβ assembly, while disrupted copper homeostasis impacts phenotype ...