Browsing Biochemistry by Title
Now showing items 1-20 of 20
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Ancient chicken remains reveal the origins of virulence in Marek's disease virus.
(2023-12-15)The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek's disease virus (MDV), which causes lymphoid ... -
Ancient mitogenomes from Pre-Pottery Neolithic Central Anatolia and the effects of a Late Neolithic bottleneck in sheep (Ovis aries).
(2024-04-12)Occupied between ~10,300 and 9300 years ago, the Pre-Pottery Neolithic site of Aşıklı Höyük in Central Anatolia went through early phases of sheep domestication. Analysis of 629 mitochondrial genomes from this and numerous ... -
A compendium of genetic regulatory effects across pig tissues.
(2024-01)The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation ... -
Copper(II) Can Kinetically Trap Arctic and Italian Amyloid‑β40 as Toxic Oligomers, Mimicking Cu(II) Binding to Wild-Type Amyloid‑β42: Implications for Familial Alzheimer’s Disease
(American Chemical Society (ACS), 2024-02-06)The self-association of amyloid-β (Aβ) peptide into neurotoxic oligomers is believed to be central to Alzheimer’s disease (AD). Copper is known to impact Aβ assembly, while disrupted copper homeostasis impacts phenotype ... -
Enzyme-cargo encapsulation peptides bind between tessellating tiles of the bacterial microcompartment shell.
(Elsevier, 2024-05-10)Bacterial microcompartments are prokaryotic organelles comprising encapsulated enzymes within a thin protein shell. They facilitate metabolic processing including propanediol, choline, glycerol, and ethanolamine utilization, ... -
The history of Coast Salish "woolly dogs" revealed by ancient genomics and Indigenous Knowledge.
(2023-12-15)Ancestral Coast Salish societies in the Pacific Northwest kept long-haired "woolly dogs" that were bred and cared for over millennia. However, the dog wool-weaving tradition declined during the 19th century, and the ... -
Impact of Membrane Phospholipids and Exosomes on the Kinetics of Amyloid-β Fibril Assembly.
(2024-03-15)Alzheimer's disease (AD) is linked with the self-association of the amyloid-β peptide (Aβ) into oligomers and fibrils. The brain is a lipid rich environment for Aβ to assemble, while the brain membrane composition varies ... -
A pangenome graph reference of 30 chicken genomes allows genotyping of large and complex structural variants.
(2023-11-22)BACKGROUND: The red junglefowl, the wild outgroup of domestic chickens, has historically served as a reference for genomic studies of domestic chickens. These studies have provided insight into the etiology of traits of ... -
Patagonian partnerships: the extinct Dusicyon avus and its interaction with prehistoric human communities.
(2024-04)The southern Mendoza province, located in the northern region of Patagonia, was inhabited by hunter-gatherer groups until historic times. Previous archaeological studies have reported canid remains among faunal assemblages, ... -
Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method.
(Elsevier, 2023-10-14)Centrosomes are the major microtubule-organizing centers in animals and play fundamental roles in many cellular processes. Understanding how their composition varies across diverse cell types and how it is altered in disease ... -
Seasonal dynamics of Arctic soils: Capturing year-round processes in measurements and soil biogeochemical models
(2024-07-01)The Arctic is undergoing rapid changes in climate, altering the status and functioning of high-latitude soils and permafrost. The vast majority of studies on Arctic soils and permafrost are conducted during the summer ... -
Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs.
(2024-03-28)Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that have emerged as a therapeutic modality to induce targeted protein degradation (TPD) by harnessing cellular proteolytic degradation machinery. ... -
Suspended particles are hotspots of microbial remineralization in the ocean's twilight zone
(Elsevier, 2023-10-22)The sinking of photosynthetically produced organic carbon from the ocean surface to its interior is a significant term in the global carbon cycle. Most sinking organic carbon is, however, remineralized in the mesopelagic ... -
Unifying the mechanism of mitotic exit control in a spatiotemporal logical model.
(Public Library of Science, 2020-11)The transition from mitosis into the first gap phase of the cell cycle in budding yeast is controlled by the Mitotic Exit Network (MEN). The network interprets spatiotemporal cues about the progression of mitosis and ensures ...