Browsing School of Biological and Chemical Sciences by Subject "gene deletion"
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Unravelling the anti-trypanosomal mechanism of benznidazole and related 2-nitroimidazoles: From prodrug activation to DNA damage.
(Wiley, 2021-06-01)Nitroheterocycles represent an important class of compound used to treat trypanosomiasis. They often function as prodrugs and can undergo type I nitroreductase (NTR1)-mediated activation before promoting their anti-parasitic ...