Browsing School of Biological and Chemical Sciences by Subject "basal body"

Now showing items 1-4 of 4

    • CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions. 

      Ochi, T; Quarantotti, V; Lin, H; Jullien, J; Rosa E Silva, I; Boselli, F; Barnabas, DD; Johnson, CM; McLaughlin, SH; Freund, SMV (2020-06-02)
      Centrioles are cylindrical assemblies whose peripheral microtubule array displays a 9-fold rotational symmetry that is established by the scaffolding protein SAS6. Centriole symmetry can be broken by centriole-associated ...

    • The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase. 

      Al-Jassar, C; Andreeva, A; Barnabas, DD; McLaughlin, SH; Johnson, CM; Yu, M; van Breugel, M (2017-01-03)
      Cilia are thin cell projections with essential roles in cell motility, fluid movement, sensing, and signaling. They are templated from centrioles that dock against the plasma membrane and subsequently extend their peripheral ...

    • Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis. 

      Joseph, N; Al-Jassar, C; Johnson, CM; Andreeva, A; Barnabas, DD; Freund, SMV; Gergely, F; van Breugel, M (2018-05-29)
      Ciliopathies are a group of genetic disorders caused by a failure to form functional cilia. Due to a lack of structural information, it is currently poorly understood how ciliopathic mutations affect protein functionality ...

    • Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies. 

      Rosa E Silva, I; Binó, L; Johnson, CM; Rutherford, TJ; Neuhaus, D; Andreeva, A; Čajánek, L; van Breugel, M (2022-01-06)
      Cilia formation is essential for human life. One of the earliest events in the ciliogenesis program is the recruitment of tau-tubulin kinase 2 (TTBK2) by the centriole distal appendage component CEP164. Due to the lack of ...