Browsing School of Biological and Chemical Sciences by Subject "Telomerase"
Now showing items 1-5 of 5
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Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.
(2009-04-08)To maintain genomic integrity, telomeres must undergo switches from a protected state to an accessible state that allows telomerase recruitment. To better understand how telomere accessibility is regulated in fission yeast, ... -
Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment.
(2009-08)The checkpoint kinases ATM and ATR are redundantly required for maintenance of stable telomeres in diverse organisms, including budding and fission yeasts, Arabidopsis, Drosophila, and mammals. However, the molecular basis ... -
Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast.
(2008-03)Fission yeast cells survive loss of the telomerase catalytic subunit Trt1 (TERT) through recombination-based telomere maintenance or through chromosome circularization. Although trt1Delta survivors with linear chromosomes ... -
Roles of heterochromatin and telomere proteins in regulation of fission yeast telomere recombination and telomerase recruitment.
(2010-02-19)When the telomerase catalytic subunit (Trt1/TERT) is deleted, a majority of fission yeast cells survives by circularizing chromosomes. Alternatively, a small minority survives by maintaining telomeric repeats through ... -
To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?
(2010-06-01)DNA damage checkpoint and DNA repair mechanisms play critical roles in the stable maintenance of genetic information. Various forms of DNA damage that arise inside cells due to common errors in normal cellular processes, ...