dc.contributor.author | Sprio, S | |
dc.contributor.author | Campodoni, E | |
dc.contributor.author | Sandri, M | |
dc.contributor.author | Preti, L | |
dc.contributor.author | Keppler, T | |
dc.contributor.author | Mueller, FA | |
dc.contributor.author | Pugno, NM | |
dc.contributor.author | Tampieri, A | |
dc.date.accessioned | 2019-03-05T16:00:02Z | |
dc.date.available | 2018-11-12 | |
dc.date.available | 2019-03-05T16:00:02Z | |
dc.date.issued | 2018-11 | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.other | ARTN 3604 | |
dc.identifier.other | ARTN 3604 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/55818 | |
dc.description.abstract | The regeneration of dental tissues is a still an unmet clinical need; in fact, no therapies have been completely successful in regenerating dental tissue complexes such as periodontium, which is also due to the lack of scaffolds that are able to guide and direct cell fate towards the reconstruction of different mineralized and non-mineralized dental tissues. In this respect, the present work develops a novel multifunctional hybrid scaffold recapitulating the different features of alveolar bone, periodontal ligament, and cementum by integrating the biomineralization process, and tape casting and electrospinning techniques. The scaffold is endowed with a superparamagnetic ability, thanks to the use of a biocompatible, bioactive superparamagnetic apatite phase, as a mineral component that is able to promote osteogenesis and to be activated by remote magnetic signals. The periodontal scaffold was obtained by engineering three different layers, recapitulating the relevant compositional and microstructural features of the target tissues, into a monolithic multifunctional graded device. Physico-chemical, morphological, and ultrastructural analyses, in association with preliminary in vitro investigations carried out with mesenchymal stem cells, confirm that the final scaffold exhibits a good mimicry of the periodontal tissue complex, with excellent cytocompatibility and cell viability, making it very promising for regenerative applications in dentistry. View Full-Text | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | |
dc.rights | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | biomimetic hybrid scaffold | en_US |
dc.subject | biomineralization | en_US |
dc.subject | electrospinning | en_US |
dc.subject | periodontal regeneration | en_US |
dc.subject | collagen | en_US |
dc.subject | superparamagnetic hydroxyapatite | en_US |
dc.title | A Graded Multifunctional Hybrid Scaffold with Superparamagnetic Ability for Periodontal Regeneration | en_US |
dc.type | Article | en_US |
dc.rights.holder | © The Author(s) 2018 | |
dc.identifier.doi | 10.3390/ijms19113604 | |
pubs.author-url | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000451528500320&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
pubs.issue | 11 | en_US |
pubs.notes | No embargo | en_US |
pubs.notes | This is the published version of the publication. Creative Commons License. | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 19 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |