Centre for Primary Care and Public Health: Recent submissions
Now showing items 21-40 of 1689
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When to stop: Transfusions, difficult conversations and creativity.
(Wiley Open Access, 2024-05-28) -
Invisible Infrastructure in Haematology: Neutrophil Reference Ranges and the Duffy-null Phenotype.
(Wiley Open Access, 2023-11) -
Seeking help for atrial fibrillation: the role of the body in distributed decision making.
(2024-06)We adopt Rapley's (2008) concept of distributed decision making to explore the role of the body in people's decisions to seek medical care. We conducted in-depth interviews with patients diagnosed with atrial fibrillation ... -
Development of a conceptual framework for defining trial efficiency
(Public Library of Science, 2024-05-23)Background Globally, there is a growing focus on efficient trials, yet numerous interpretations have emerged, suggesting a significant heterogeneity in understanding “efficiency” within the trial context. Therefore in ... -
The growing burden of atrial fibrillation and its consequences.
(BMJ Publishing Group, 2024-04-17) -
Determining households from patient addresses and unique property reference numbers in general practitioner electronic health records
(Swansea University, 2024-04-09)Introduction Households are increasingly studied in population health research as an important context for understanding health and social behaviours and outcomes. Identifying household units of analysis in routinely ... -
Factors Influencing Recovery From Pediatric Stroke Based on Discussions From a UK-Based Online Stroke Community: Qualitative Thematic Study.
(2024-04-16)BACKGROUND: The incidence of stroke in children is low, and pediatric stroke rehabilitation services are less developed than adult ones. Survivors of pediatric stroke have a long poststroke life expectancy and therefore ... -
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.
(Nature Research, 2024-01-30)To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including ... -
Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function
(Springer, 2022-03-05)Aims/hypothesis South Asians in general, and Asian Indians in particular, have higher risk of type 2 diabetes compared with white Europeans, and a younger age of onset. The reasons for the younger age of onset in relation ... -
The cholesterol-lowering effect of statins is modified by LILRB5 intolerance genotype: Results from a recruit-by-genotype clinical trial
(Frontiers Media, 2023-03-14)Background/Aims: Statin intolerance leads to poor adherence to statin therapy, resulting in a failure to achieve desired cholesterol reduction and adverse outcomes. The LILRB5 Asp247Gly genotype has been identified as being ... -
Weight variability and cardiovascular outcomes: a systematic review and meta-analysis
(BMC, 2023-01-09)The association between body weight variability and the risk of cardiovascular disease (CVD) has been investigated previously with mixed findings. However, there has been no extensive study which systematically evaluates ... -
Major cardiovascular events and subsequent risk of kidney failure with replacement therapy: a CKD Prognosis Consortium study
(Oxford University Press, 2023-01-24)Aims Chronic kidney disease (CKD) increases risk of cardiovascular disease (CVD). Less is known about how CVD associates with future risk of kidney failure with replacement therapy (KFRT). Methods and results The study ... -
Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations
(American Diabetes Association, 2023-06-12)OBJECTIVE South Asians are diagnosed with type 2 diabetes (T2D) more than a decade earlier in life than seen in European populations. We hypothesized that studying the genomics of age of diagnosis in these populations may ... -
Competing risks analysis for neutrophil to lymphocyte ratio as a predictor of diabetic retinopathy incidence in the Scottish population
(BMC, 2023-08-10)Background Diabetic retinopathy (DR) is a major sight-threatening microvascular complication in individuals with diabetes. Systemic inflammation combined with oxidative stress is thought to capture most of the complexities ... -
A gene risk score using missense variants in SLCO1B1 is associated with earlier onset statin intolerance
(Oxford University Press, 2023-05-30)Background and aims The efficacy of statin therapy is hindered by intolerance to the therapy, leading to discontinuation. Variants in SLCO1B1, which encodes the hepatic transporter OATB1B1, influence statin pharmacokinetics, ... -
Secular trends in the prevalence of diabetes and prediabetes among the rural population of South India
(Springer, 2023-05-02)Objective This study aimed to assess the secular trends in the prevalence of diabetes and pre-diabetes from two cross-sectional studies done 11 years apart, in rural Tamil Nadu. Methods The Telemedicine PRoject for ... -
Addressing Ancestry and Sex Bias in Pharmacogenomics.
(Annual Reviews, 2023-07-14)The association of an individual's genetic makeup with their response to drugs is referred to as pharmacogenomics. By understanding the relationship between genetic variants and drug efficacy or toxicity, we are able to ... -
What is the environmental impact of a blood transfusion? A life cycle assessment of transfusion services across England.
(2024-03-20)BACKGROUND: Healthcare activities significantly contribute to greenhouse gas (GHG) emissions. Blood transfusions require complex, interlinked processes to collect, manufacture, and supply. Their contribution to healthcare ...