dc.contributor.author | Jolliffe, DA | |
dc.contributor.author | Ganmaa, D | |
dc.contributor.author | Wejse, C | |
dc.contributor.author | Raqib, R | |
dc.contributor.author | Haq, MA | |
dc.contributor.author | Salahuddin, N | |
dc.contributor.author | Daley, PK | |
dc.contributor.author | Ralph, AP | |
dc.contributor.author | Ziegler, TR | |
dc.contributor.author | Martineau, AR | |
dc.date.accessioned | 2019-02-28T13:06:05Z | |
dc.date.available | 2019-02-28T13:06:05Z | |
dc.date.issued | 2019-02-06 | |
dc.identifier.citation | Jolliffe, D. A., et al. (2019). "Adjunctive vitamin D in tuberculosis treatment: meta-analysis of individual participant data." European Respiratory Journal: 1802003. | en_US |
dc.identifier.issn | 0903-1936 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/55613 | |
dc.description | “This is an author-submitted, peer-reviewed version of a manuscript that has been accepted for publication in the European Respiratory Journal, prior to copy-editing, formatting and typesetting. This version of the manuscript may not be duplicated or reproduced without prior permission from the copyright owner, the European Respiratory Society. The publisher is not responsible or liable for any errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final, copy-edited, published article, which is the version of record, is available without a subscription 18 months after the date of issue publication.” | en_US |
dc.description.abstract | BACKGROUND: Randomised controlled trials (RCTs) of adjunctive vitamin D in pulmonary tuberculosis (PTB) treatment have yielded conflicting results. Individual participant data (IPD) meta-analysis could identify factors explaining this variation. METHODS: We meta-analysed IPD from RCTs of vitamin D in patients receiving antimicrobial therapy for PTB. Primary outcome was time to sputum culture conversion. Secondary outcomes were time to sputum smear conversion, mean 8-week weight and incidence of adverse events. Pre-specified sub-group analyses were done according to baseline vitamin D status, age, sex, drug-susceptibility, HIV status, extent of disease, and vitamin D receptor genotype. RESULTS: IPD were obtained for 1850 participants in 8 studies. Vitamin D did not influence time to sputum culture conversion overall (aHR 1.06, 95% CI 0.91-1.23), but it did accelerate sputum culture conversion in participants with multidrug-resistant PTB (aHR 13.44, 95% CI 2.96-60.90); no such effect was seen in those whose isolate was sensitive to rifampicin and/or isoniazid (aHR 1.02, 95% CI 0.88-1.19; Pinteraction=0.02). Vitamin D accelerated sputum smear conversion overall (aHR 1.15, 95% CI 1.01-1.31), but did not influence other secondary outcomes. CONCLUSIONS: Vitamin D did not influence time to sputum culture conversion overall, but it accelerated sputum culture conversion in patients with multidrug-resistant PTB. | en_US |
dc.description.sponsorship | ARM and DAJ are supported by the Higher Education Funding Council for England (HEFCE). | en_US |
dc.language | eng | |
dc.language.iso | en | en_US |
dc.publisher | European Respiratory Society | en_US |
dc.relation.ispartof | Eur Respir J | |
dc.subject | Vitamin D | en_US |
dc.subject | Tuberculosis | en_US |
dc.title | Adjunctive vitamin D in tuberculosis treatment: meta-analysis of individual participant data. | en_US |
dc.type | Article | en_US |
dc.rights.holder | ERS 2019 | |
dc.identifier.doi | 10.1183/13993003.02003-2018 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30728208 | en_US |
pubs.notes | No embargo | en_US |
pubs.publication-status | Published online | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |