| dc.contributor.author | Song, T | en_US |
| dc.contributor.author | Arseniyadis, S | en_US |
| dc.contributor.author | Cossy, J | en_US |
| dc.date.accessioned | 2019-01-22T11:47:41Z | |
| dc.date.available | 2019-01-10 | en_US |
| dc.date.issued | 2019-02-01 | en_US |
| dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/54837 | |
| dc.description.abstract | The synthesis of chiral unsaturated γ-lactams is reported featuring a highly enantioselective palladium-catalyzed asymmetric allylic alkylation of α,γ-disubstituted 2-silyloxypyrroles. This method allows a straightforward access to optically active γ-lactams bearing an α-quaternary stereogenic center in high yields (up to 93%), high regioselectivities (up to >20:1), and excellent enantioselectivities (up to 95% ee). To further demonstrate the synthetic utility of the method, the resulting allylated products were converted to various versatile chiral building blocks, such as pyrrolidines and pyrrolidinones. | en_US |
| dc.format.extent | 603 - 607 | en_US |
| dc.language | eng | en_US |
| dc.relation.ispartof | Org Lett | en_US |
| dc.rights | This is a pre-copyedited, author-produced version of an article accepted for publication in Organic Letters following peer review. The version of record is available https://pubs.acs.org/doi/10.1021/acs.orglett.8b03613 | |
| dc.title | Asymmetric Synthesis of α-Quaternary γ-Lactams through Palladium-Catalyzed Asymmetric Allylic Alkylation. | en_US |
| dc.type | Article | |
| dc.rights.holder | Copyright © 2019 American Chemical Society | |
| dc.identifier.doi | 10.1021/acs.orglett.8b03613 | en_US |
| pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30645137 | en_US |
| pubs.issue | 3 | en_US |
| pubs.notes | Not known | en_US |
| pubs.publication-status | Published | en_US |
| pubs.volume | 21 | en_US |
| rioxxterms.funder | Default funder | en_US |
| rioxxterms.identifier.project | Default project | en_US |
