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Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia

dc.contributor.authorDunyo, S
dc.contributor.authorSirugo, G
dc.contributor.authorSesay, S
dc.contributor.authorBisseye, C
dc.contributor.authorNjie, F
dc.contributor.authorAdiamoh, M
dc.contributor.authorNwakanma, D
dc.contributor.authorDiatta, M
dc.contributor.authorJanha, R
dc.contributor.authorSisay Joof, F
dc.contributor.authorTemple, B
dc.contributor.authorSnell, P
dc.contributor.authorConway, D
dc.contributor.authorWalton, R
dc.contributor.authorCheung, YB
dc.contributor.authorMilligan, P
dc.date.accessioned2014-01-28T15:18:02Z
dc.date.available2014-01-28T15:18:02Z
dc.date.issued2011
dc.identifier.citationDunyo S, Sirugo G, Sesay S, Bisseye C, Njie F, et al. (2011) Randomized Trial of Safety and Effectiveness of Chlorproguanil-Dapsone and Lumefantrine-Artemether for Uncomplicated Malaria in Children in The Gambia. PLoS ONE 6(6): e17371. doi:10.1371/journal.pone.0017371
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/5432
dc.descriptionPMCID: PMC3110183
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.abstractChlorproguanil-dapsone (Lapdap), developed as a low-cost antimalarial, was withdrawn in 2008 after concerns about safety in G6PD deficient patients. This trial was conducted in 2004 to evaluate the safety and effectiveness of CD and comparison with artemether-lumefantrine (AL) under conditions of routine use in G6PD normal and G6PD deficient patients with uncomplicated malaria in The Gambia. We also examined the effects of a common genetic variant that affects chlorproguanil metabolism on risk of treatment failure.
dc.format.extente17371 - ?
dc.languageeng
dc.subjectAnimals
dc.subjectAntimalarials
dc.subjectArtemisinins
dc.subjectAryl Hydrocarbon Hydroxylases
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectDapsone
dc.subjectDrug Combinations
dc.subjectEthanolamines
dc.subjectFemale
dc.subjectFluorenes
dc.subjectGambia
dc.subjectGenotype
dc.subjectGlucosephosphate Dehydrogenase
dc.subjectHemoglobins
dc.subjectHumans
dc.subjectIncidence
dc.subjectInfant
dc.subjectMalaria
dc.subjectMale
dc.subjectParasites
dc.subjectPatient Compliance
dc.subjectProguanil
dc.subjectTreatment Failure
dc.subjectTreatment Outcome
dc.titleRandomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia
dc.identifier.doi10.1371/journal.pone.0017371
dc.relation.isPartOfPLoS One
pubs.author-urlhttp://www.ncbi.nlm.nih.gov/pubmed/21666744
pubs.declined2013-09-30T14:58:15.866+0100
pubs.issue6
pubs.volume6


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