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dc.contributor.authorDereka, Xen_US
dc.contributor.authorCalciolari, Een_US
dc.contributor.authorDonos, Nen_US
dc.contributor.authorMardas, Nen_US
dc.date.accessioned2018-11-15T08:52:40Z
dc.date.available2018-03-28en_US
dc.date.issued2018-12en_US
dc.date.submitted2018-06-01T11:43:21.346Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/50703
dc.description.abstractOsteoporosis is one of the most common skeletal disorders affecting a significant percentage of people worldwide. Research data suggested that systemic diseases such as osteoporosis could act as risk factors for osseointegration, jeopardizing the healing process and thus the predictability of dental implant success on compromised patients. It is well accepted that preclinical studies in animal models reproducing the osteoporotic condition are one of the most important stages in the research of new biomaterials and therapeutic modalities. The aim of this systematic review was to investigate whether osteoporosis compromises dental implant osseointegration in experimental osteoporotic-like conditions. A 3-stage systematic literature research was conducted in MEDLINE via OVID and EMBASE up to and including March 2017. Experimental studies reporting on dental implant osseointegration on different osteoporotic animal models were assessed. The studies had to report on the percentage of bone-to-implant contact (%BIC) as the primary outcome. ARRIVE guidelines for reporting on animal research were applied to evaluate the methodological quality and risk of bias of the studies. Fifty-seven studies met the inclusion criteria and were assessed qualitatively. The most adopted animal model was the rat. A variability of %BIC values was observed, ranging from 30% to 99% and from 26% to 94% for the healthy and osteoporotic group, respectively. The great majority (47) of the included studies concluded that estrogen deficiency significantly affects BIC values, 9 studies stated that it was not possible to observe statistical differences in BIC between ovariectomized and healthy groups and 1 study did not provide a comparison between the healthy and osteoporotic group. Owing to the great heterogeneity in implant surface, study design, observation time-points, site of implant placement and reported outcomes, a meta-analysis could not be performed. An overall high risk of bias was observed, owing to the limited information on animal housing and husbandry, baseline characteristics and health status, ethical statement and allocation to the experimental groups provided. Although the available studies seem to suggest a lower osseointegration in osteoporotic-like conditions, no robust conclusions can be drawn due to the great heterogeneity and overall low quality of the available studies. Future studies with emphasis on minimizing the possible sources of bias and evaluating osseointegration of dental implants placed into jawbones instead of long bones are warranted.en_US
dc.format.extent933 - 940en_US
dc.languageengen_US
dc.relation.ispartofJ Periodontal Resen_US
dc.rightsThis is the peer reviewed version of the following article: Dereka X, Calciolari E, Donos N, Mardas N. Osseointegration in osteoporotic-like condition: A systematic review of preclinical studies. J Periodont Res. 2018;53:933–940., which has been published in final form at https://doi.org/10.1111/jre.12566. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.subjectanimalsen_US
dc.subjectosseointegrationen_US
dc.subjectosteoporosisen_US
dc.subjectpreclinical studiesen_US
dc.subjectsystematic reviewen_US
dc.titleOsseointegration in osteoporotic-like condition: A systematic review of preclinical studies.en_US
dc.typeArticle
dc.rights.holder© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
dc.identifier.doi10.1111/jre.12566en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29845622en_US
pubs.issue6en_US
pubs.notes12 monthsen_US
pubs.publication-statusPublisheden_US
pubs.volume53en_US
dcterms.dateAccepted2018-03-28en_US


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