dc.contributor.author | Saleem, J | en_US |
dc.contributor.author | Zakar, R | en_US |
dc.contributor.author | Zakar, MZ | en_US |
dc.contributor.author | Belay, M | en_US |
dc.contributor.author | Rowe, M | en_US |
dc.contributor.author | Timms, PM | en_US |
dc.contributor.author | Scragg, R | en_US |
dc.contributor.author | Martineau, AR | en_US |
dc.date.accessioned | 2018-05-10T15:01:00Z | |
dc.date.available | 2018-02-01 | en_US |
dc.date.issued | 2018-05-01 | en_US |
dc.date.submitted | 2018-05-10T11:24:26.683Z | |
dc.identifier.other | 10.1093/ajcn/nqy027 | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/37483 | |
dc.description | This is a pre-copyedited, author-produced version of an article accepted for publication in American Journal of Clinical Nutrition following peer review. The version of record Saleem, J., et al. (2018). "High-dose vitamin D3 in the treatment of severe acute malnutrition: a multicenter double-blind randomized controlled trial." The American Journal of Clinical Nutrition 107(5): 725-733. is available online at:https://doi.org/10.1093/ajcn/nqy027 | en_US |
dc.description.abstract | Background: Vitamin D deficiency is common in children with severe acute malnutrition, in whom it is associated with severe wasting. Ready-to-use therapeutic food (the standard treatment) contains modest amounts of vitamin D that do not reliably correct deficiency. Objective: The aim of this study was to determine whether high-dose oral vitamin D3 enhances weight gain and development in children with uncomplicated severe acute malnutrition. Design: We conducted a randomized placebo-controlled trial of high-dose vitamin D3 supplementation in children aged 6-58 mo with uncomplicated severe acute malnutrition in Pakistan. Participants were randomly assigned to receive 2 oral doses of 200,000 IU vitamin D3 or placebo at 2 and 4 wk after starting ready-to-use therapeutic food. The primary outcome was the proportion of participants gaining >15% of baseline weight at 8 wk after starting ready-to-use therapeutic food (the end of the study). Secondary outcomes were mean weight-for-height or -length z score and the proportion of participants with delayed development at the end of the study (assessed with the Denver Development Screening Tool II), adjusted for baseline values. Results: Of the 194 randomly assigned children who started the study, 185 completed the follow-up and were included in the analysis (93 assigned to intervention, 92 to control). High-dose vitamin D3 did not influence the proportion of children gaining >15% of baseline weight at the end of the study (RR: 1.04; 95% CI: 0.94,1.15, P = 0.47), but it did increase the weight-for-height or -length z score (adjusted mean difference: 1.07; 95% CI: 0.49,1.65, P < 0.001) and reduce the proportion of participants with delayed global development [adjusted RR (aRR): 0.49; 95% CI: 0.31, 0.77, P = 0.002], delayed gross motor development (aRR: 0.29; 95% CI: 0.13, 0.64, P = 0.002), delayed fine motor development (aRR: 0.59; 95% CI: 0.38, 0.91, P = 0.018), and delayed language development (aRR: 0.57; 95% CI: 0.34, 0.96, P = 0.036). Conclusions: High-dose vitamin D3 improved the mean weight-for-height or -length z score and developmental indexes in children receiving standard therapy for uncomplicated severe acute malnutrition in Pakistan. This trial was registered at clinicaltrials.gov as NCT03170479. | en_US |
dc.description.sponsorship | Supported by a grant from the Higher Education Commission of Pakistan
under its International Research Support Initiative Program (IRSIP), reference
no. 1-8/HEC/HRD/2016/6029 | en_US |
dc.format.extent | 725 - 733 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Am J Clin Nutr | en_US |
dc.rights | All rights reserved. | |
dc.rights | This is a pre-copyedited, author-produced version of an article accepted for publication in American Journal of Clinical Nutrition, following peer review. The version of record: Javeria Saleem, Rubeena Zakar, Muhammad Z Zakar, Mulugeta Belay, Marion Rowe, Peter M Timms, Robert Scragg, Adrian R Martineau, High-dose vitamin D3 in the treatment of severe acute malnutrition: a multicenter double-blind randomized controlled trial, The American Journal of Clinical Nutrition, Volume 107, Issue 5, May 2018, Pages 725–733, doi:10.1093/ajcn/nqy027 is available online at: https://doi.org/10.1093/ajcn/nqy027 | |
dc.subject | Child Nutrition Disorders | en_US |
dc.subject | Child, Preschool | en_US |
dc.subject | Cholecalciferol | en_US |
dc.subject | Diet | en_US |
dc.subject | Dose-Response Relationship, Drug | en_US |
dc.subject | Double-Blind Method | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Infant | en_US |
dc.subject | Infant Nutrition Disorders | en_US |
dc.subject | Male | en_US |
dc.subject | Vitamins | en_US |
dc.title | High-dose vitamin D3 in the treatment of severe acute malnutrition: a multicenter double-blind randomized controlled trial. | en_US |
dc.type | Article | |
dc.rights.holder | 2018 American Society for Nutrition. | |
dc.identifier.doi | 10.1093/ajcn/nqy027 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/29722846 | en_US |
pubs.issue | 5 | en_US |
pubs.notes | No embargo | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 107 | en_US |
dcterms.dateAccepted | 2018-02-01 | en_US |