dc.contributor.author | Ramich, T | en_US |
dc.contributor.author | Asendorf, A | en_US |
dc.contributor.author | Nickles, K | en_US |
dc.contributor.author | Oremek, GM | en_US |
dc.contributor.author | Schubert, R | en_US |
dc.contributor.author | Nibali, L | en_US |
dc.contributor.author | Wohlfeil, M | en_US |
dc.contributor.author | Eickholz, P | en_US |
dc.date.accessioned | 2018-05-09T15:57:39Z | |
dc.date.available | 2018-02-16 | en_US |
dc.date.issued | 2018-12 | en_US |
dc.date.submitted | 2018-03-15T09:56:43.132Z | |
dc.identifier.other | 10.1007/s00784-018-2398-x | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/37185 | |
dc.description | “This is a post-peer-review, pre-copy edit version of an article published in Clinical Oral Investigations. The final authenticated version is available online at: https://doi.org/10.1007/s00784-018-2398-x”. | en_US |
dc.description.abstract | AIM: The aim of the study is to assess the long-term effect of active periodontal therapy on serum inflammatory parameters in patients with aggressive (AgP) and chronic (ChP) periodontitis in a non-randomised clinical study. METHODS: Twenty-five ChP and 17 AgP were examined clinically prior to (baseline), 12 weeks and 60 months after subgingival debridement of all pockets within 2 days. Systemic antibiotics were prescribed if Aggregatibacter actinomycetemcomitans was detected (10 AgP, 8 ChP), flap surgery was rendered if required. Neutrophil elastase (NE), C-reactive protein (CRP), lipopolysaccharide binding protein, interleukin 6, 8, and leukocyte counts were assessed at baseline, 12 weeks and 60 months. RESULTS: Clinical parameters improved significantly in both groups from 12 weeks to 60 months. Eleven AgP and 18 ChP patients received surgical treatment after the 12 weeks examination. Only 3 patients in each group attended ≥ 2 supportive maintenance visits per year. NE and CRP were significantly higher in AgP than ChP at baseline and 60 months (p < 0.01). For leukocyte counts in ChP, significant changes were observed (baseline: 6.11 ± 1.44 nl-1; 12 weeks: 5.34 ± 1.40 nl-1; 60 months: 7.73 ± 2.89 nl-1; p < 0.05). Multiple regression analysis identified African origin, surgical treatment and female sex to correlate with better clinical improvement. CONCLUSION: Despite comprehensive periodontal treatment, AgP patients exhibit higher NE and CRP levels than ChP patients up to 5 years after therapy. CLINICAL RELEVANCE: Systemic inflammatory burden in AgP patients is higher than in ChP patients even 5 years after periodontal treatment. | en_US |
dc.format.extent | 3079 - 3089 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Clin Oral Investig | en_US |
dc.rights | Creative Commons Attribution License | |
dc.subject | Aggressive periodontitis | en_US |
dc.subject | C-reactive protein | en_US |
dc.subject | Chronic periodontitis | en_US |
dc.subject | Interleukin-6 | en_US |
dc.subject | Leukocyte elastase | en_US |
dc.subject | Lipopolysaccharide-binding protein | en_US |
dc.title | Inflammatory serum markers up to 5 years after comprehensive periodontal therapy of aggressive and chronic periodontitis. | en_US |
dc.type | Article | |
dc.rights.holder | The Author(s) 2018 | |
dc.identifier.doi | 10.1007/s00784-018-2398-x | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/29484548 | en_US |
pubs.issue | 9 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 22 | en_US |
dcterms.dateAccepted | 2018-02-16 | en_US |