dc.contributor.author | Beyer, SE | en_US |
dc.contributor.author | Sanghvi, MM | en_US |
dc.contributor.author | Aung, N | en_US |
dc.contributor.author | Hosking, A | en_US |
dc.contributor.author | Cooper, JA | en_US |
dc.contributor.author | Paiva, JM | en_US |
dc.contributor.author | Lee, AM | en_US |
dc.contributor.author | Fung, K | en_US |
dc.contributor.author | Lukaschuk, E | en_US |
dc.contributor.author | Carapella, V | en_US |
dc.contributor.author | Mittleman, MA | en_US |
dc.contributor.author | Brage, S | en_US |
dc.contributor.author | Piechnik, SK | en_US |
dc.contributor.author | Neubauer, S | en_US |
dc.contributor.author | Petersen, SE | en_US |
dc.date.accessioned | 2018-04-27T10:20:24Z | |
dc.date.available | 2018-02-15 | en_US |
dc.date.issued | 2018 | en_US |
dc.date.submitted | 2018-03-01T08:22:49.970Z | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/36544 | |
dc.description.abstract | BACKGROUND: Handgrip strength, a measure of muscular fitness, is associated with cardiovascular (CV) events and CV mortality but its association with cardiac structure and function is unknown. The goal of this study was to determine if handgrip strength is associated with changes in cardiac structure and function in UK adults. METHODS AND RESULTS: Left ventricular (LV) ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), mass (M), and mass-to-volume ratio (MVR) were measured in a sample of 4,654 participants of the UK Biobank Study 6.3 ± 1 years after baseline using cardiovascular magnetic resonance (CMR). Handgrip strength was measured at baseline and at the imaging follow-up examination. We determined the association between handgrip strength at baseline as well as its change over time and each of the cardiac outcome parameters. After adjustment, higher level of handgrip strength at baseline was associated with higher LVEDV (difference per SD increase in handgrip strength: 1.3ml, 95% CI 0.1-2.4; p = 0.034), higher LVSV (1.0ml, 0.3-1.8; p = 0.006), lower LVM (-1.0g, -1.8 --0.3; p = 0.007), and lower LVMVR (-0.013g/ml, -0.018 --0.007; p<0.001). The association between handgrip strength and LVEDV and LVSV was strongest among younger individuals, while the association with LVM and LVMVR was strongest among older individuals. CONCLUSIONS: Better handgrip strength was associated with cardiac structure and function in a pattern indicative of less cardiac hypertrophy and remodeling. These characteristics are known to be associated with a lower risk of cardiovascular events. | en_US |
dc.description.sponsorship | KF is supported by The Medical College of Saint Bartholomew’s Hospital Trust, an independent registered charity that promotes and advances medical and dental education and research at Barts and The London School of Medicine and Dentistry. AL and SEP acknowledge support from the NIHR Cardiovascular Biomedical Research Centre at Barts and from the “SmartHeart” EPSRC program grant (EP/P001009/1). SN and SKP are supported by the Oxford NIHR Biomedical Research Centre and the Oxford British Heart Foundation Centre of Research Excellence. This project was enabled through access to the MRC eMedLab Medical Bioinformatics infrastructure, supported by the Medical Research Council (grant number MR/L016311/1). The work of SB was funded by the Medical Research Council (MC_UU_12015/3). NA is supported by a Wellcome Trust Research Training Fellowship (203553/Z/Z). The authors SEP, SN and SKP acknowledge the British Heart Foundation (BHF) for funding the manual analysis to create a cardiovascular magnetic resonance imaging reference standard for the UK Biobank imaging resource in 5000 CMR scans (PG/14/89/31194). | en_US |
dc.format.extent | e0193124 - ? | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | PLoS One | en_US |
dc.subject | Adult | en_US |
dc.subject | Aged | en_US |
dc.subject | Cardiovascular Diseases | en_US |
dc.subject | Female | en_US |
dc.subject | Hand Strength | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Prospective Studies | en_US |
dc.subject | Stroke Volume | en_US |
dc.subject | Ventricular Function, Left | en_US |
dc.title | Prospective association between handgrip strength and cardiac structure and function in UK adults. | en_US |
dc.type | Article | |
dc.rights.holder | © 2018 Beyer et al. | |
dc.identifier.doi | 10.1371/journal.pone.0193124 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/29538386 | en_US |
pubs.issue | 3 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 13 | en_US |
dcterms.dateAccepted | 2018-02-05 | en_US |
qmul.funder | “Creation of cardiovascular magnetic resonance imaging reference standard for the UK Biobank imaging resource”::British Heart Foundation | en_US |
qmul.funder | “Creation of cardiovascular magnetic resonance imaging reference standard for the UK Biobank imaging resource”::British Heart Foundation | en_US |
qmul.funder | “Creation of cardiovascular magnetic resonance imaging reference standard for the UK Biobank imaging resource”::British Heart Foundation | en_US |
qmul.funder | “Creation of cardiovascular magnetic resonance imaging reference standard for the UK Biobank imaging resource”::British Heart Foundation | en_US |