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Modelling population-level impact to inform target product profiles for childhood malaria vaccines.
(2018-07-13)
BACKGROUND: The RTS,S/AS01 vaccine for Plasmodium falciparum malaria demonstrated moderate efficacy in 5-17-month-old children in phase 3 trials, and from 2018, the vaccine will be evaluated through a large-scale pilot ...
A unifying framework for measuring weighted rich clubs.
(2014-12-01)
Network analysis can help uncover meaningful regularities in the organization of complex systems. Among these, rich clubs are a functionally important property of a variety of social, technological and biological networks. ...
Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Naïve and Vaccinated Hosts.
(2017-01)
Over a century since Ronald Ross discovered that malaria is caused by the bite of an infectious mosquito it is still unclear how the number of parasites injected influences disease transmission. Currently it is assumed ...
Modelling collinear and spatially correlated data.
(2016-08)
In this work we present a statistical approach to distinguish and interpret the complex relationship between several predictors and a response variable at the small area level, in the presence of (i) high correlation between ...
The interaction between seasonality and pulsed interventions against malaria in their effects on the reproduction number.
(2015-01)
The basic reproduction number (R0) is an important quantity summarising the dynamics of an infectious disease, as it quantifies how much effort is needed to control transmission. The relative change in R0 due to an ...
Role of the central cations in the mechanical unfolding of DNA and RNA G-quadruplexes.
(2015-09-03)
Cations are known to mediate diverse interactions in nucleic acids duplexes but they are critical in the arrangement of four-stranded structures. Here, we use all-atom molecular dynamics simulations with explicit solvent ...
A Topological Criterion for Filtering Information in Complex Brain Networks.
(2017-01)
In many biological systems, the network of interactions between the elements can only be inferred from experimental measurements. In neuroscience, non-invasive imaging tools are extensively used to derive either structural ...
Multiscale modeling of brain dynamics: from single neurons and networks to mathematical tools.
(2016-09)
The extreme complexity of the brain naturally requires mathematical modeling approaches on a large variety of scales; the spectrum ranges from single neuron dynamics over the behavior of groups of neurons to neuronal network ...
Estimating the most efficient allocation of interventions to achieve reductions in Plasmodium falciparum malaria burden and transmission in Africa: a modelling study.
(2016-07)
BACKGROUND: Reducing the burden of malaria is a global priority, but financial constraints mean that available resources must be allocated rationally to maximise their effect. We aimed to develop a model to estimate the ...
The impact of pyrethroid resistance on the efficacy and effectiveness of bednets for malaria control in Africa.
(2016-08-22)
Long lasting pyrethroid treated bednets are the most important tool for preventing malaria. Pyrethroid resistant Anopheline mosquitoes are now ubiquitous in Africa, though the public health impact remains unclear, impeding ...
