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Now showing items 1-10 of 17
Modelling population-level impact to inform target product profiles for childhood malaria vaccines.
(2018-07-13)
BACKGROUND: The RTS,S/AS01 vaccine for Plasmodium falciparum malaria demonstrated moderate efficacy in 5-17-month-old children in phase 3 trials, and from 2018, the vaccine will be evaluated through a large-scale pilot ...
A unifying framework for measuring weighted rich clubs.
(2014-12-01)
Network analysis can help uncover meaningful regularities in the organization of complex systems. Among these, rich clubs are a functionally important property of a variety of social, technological and biological networks. ...
Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Naïve and Vaccinated Hosts.
(2017-01)
Over a century since Ronald Ross discovered that malaria is caused by the bite of an infectious mosquito it is still unclear how the number of parasites injected influences disease transmission. Currently it is assumed ...
Modelling collinear and spatially correlated data.
(2016-08)
In this work we present a statistical approach to distinguish and interpret the complex relationship between several predictors and a response variable at the small area level, in the presence of (i) high correlation between ...
The interaction between seasonality and pulsed interventions against malaria in their effects on the reproduction number.
(2015-01)
The basic reproduction number (R0) is an important quantity summarising the dynamics of an infectious disease, as it quantifies how much effort is needed to control transmission. The relative change in R0 due to an ...
Role of the central cations in the mechanical unfolding of DNA and RNA G-quadruplexes.
(2015-09-03)
Cations are known to mediate diverse interactions in nucleic acids duplexes but they are critical in the arrangement of four-stranded structures. Here, we use all-atom molecular dynamics simulations with explicit solvent ...
A Topological Criterion for Filtering Information in Complex Brain Networks.
(2017-01)
In many biological systems, the network of interactions between the elements can only be inferred from experimental measurements. In neuroscience, non-invasive imaging tools are extensively used to derive either structural ...
Motor-commands decoding using peripheral nerve signals: a review.
(2018-06)
During the last few decades, substantial scientific and technological efforts have been focused on the development of neuroprostheses. The major emphasis has been on techniques for connecting the human nervous system with ...
A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemic.
(PLoS, 2020)
As the number of cases of COVID-19 continues to grow, local health services are at risk of being overwhelmed with patients requiring intensive care. We develop and implement an algorithm to provide optimal re-routing ...
The US President's Malaria Initiative, Plasmodium falciparum transmission and mortality: A modelling study.
(2017-11)
BACKGROUND: Although significant progress has been made in reducing malaria transmission globally in recent years, a large number of people remain at risk and hence the gains made are fragile. Funding lags well behind ...