Browsing School of Engineering and Materials Science by Author "Lee, DA"
Now showing items 1-20 of 20
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Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells
Heo, S-J; Thorpe, SD; Driscoll, TP; Duncan, RL; Lee, DA; Mauck, RL (2015-11-23) -
Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion
Sliogeryte, K; Botto, L; Lee, DA; Knight, MM (2016-05) -
Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells
Pattappa, G; Thorpe, SD; Jegard, NC; Heywood, HK; de Bruijn, JD; Lee, DA (2013-01) -
Covariation of Pluripotency Markers and Biomechanical Properties in Mouse Embryonic Stem Cells
Brookes, O; Thorpe, SD; Rigby Evans, O; Keeling, MC; Lee, DA (2022) -
Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckcio optimization algorithm and harmony search for cancer classification
Elyasigomari, V; Lee, DA; Screen, HRC; Shaheed, MH (2017-03) -
Differentiation alters stem cell nuclear architecture, mechanics, and mechanosensitivity
Heo, S-J; Driscoll, TP; Thorpe, SD; Nerurkar, NL; Baker, BM; Yang, MT; Chen, CS; Lee, DA; Mauck, RL (2016-11-30) -
Does lamin A/C play a role in neuronal differentiation?
Eraifej, J; Thorpe, SD; Martins, RP; Lee, DA (2017-02) -
Dynamic compression counteracts IL-1 beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs
Chowdhury, TT; Arghandawi, S; Brand, J; Akanji, OO; Bader, DL; Salter, DM; Lee, DA (2008) -
G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization
Lachowski, D; Cortes, E; Matellan, C; Rice, A; Lee, DA; Thorpe, SD; del Río Hernández, AE (Frontiers Media, 2020-10-22) -
GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA.
Rice, A; Cortes, E; Lachowski, D; Oertle, P; Matellan, C; Thorpe, SD; Ghose, R; Wang, H; Lee, DA; Plodinec, M (2020-01-25)The invasive properties of cancer cells are intimately linked to their mechanical phenotype, which can be regulated by intracellular biochemical signalling. Cell contractility, induced by mechanotransduction of a stiff ... -
GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.
Cortes, E; Sarper, M; Robinson, B; Lachowski, D; Chronopoulos, A; Thorpe, SD; Lee, DA; Del Río Hernández, AE (2019-01)The mechanical properties of the tumor microenvironment are emerging as attractive targets for the development of therapies. Tamoxifen, an agonist of the G protein-coupled estrogen receptor (GPER), is widely used to treat ... -
Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems.
Heywood, HK; Gardner, L; Knight, MM; Lee, DA (2022)PURPOSE: In vivo, the circadian clock drives 24-h rhythms in human physiology. Isolated cells in vitro retain a functional clockwork but lack necessary timing cues resulting in the rapid loss of tissue-level circadian ... -
Oxygen tension modulates the effects of TNF alpha in compressed chondrocytes
Tilwani, RK; Vessillier, S; Pingguan-Murphy, B; Lee, DA; Bader, DL; Chowdhury, TT (2017-01) -
Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics
Sliogeryte, K; Thorpe, SD; Lee, DA; Botto, L; Knight, MM (2014-12-04) -
Stem cell differentiation state modulates Lamin AC localization and phosphorylation in response to cyclic tensile strain
Thorpe, SD; Oti, A; Mauck, RL; Lee, DA (2017-02) -
Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway
Chronopoulos, A; Thorpe, SD; Cortes, E; Lachowski, D; Rice, AJ; Mykuliak, VV; Rog, T; Lee, DA; Hytonen, VP; Hernandez, AEDR (2020-01-06) -
Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor
Cortes, E; Lachowski, D; Rice, A; Thorpe, SD; Robinson, B; Yeldag, G; Lee, DA; Ghemtio, L; Rombouts, K; Hernandez, AEDR (2019-04-18) -
Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival
Cortes, E; Lachowski, D; Robinson, B; Sarper, M; Teppo, JS; Thorpe, SD; Lieberthal, TJ; Iwamoto, K; Lee, DA; Okada-Hatakeyama, M (2019-01)