Browsing School of Engineering and Materials Science by Author "Lachowski, D"
Now showing items 1-6 of 6
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G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization
Lachowski, D; Cortes, E; Matellan, C; Rice, A; Lee, DA; Thorpe, SD; del Río Hernández, AE (Frontiers Media, 2020-10-22) -
GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA.
Rice, A; Cortes, E; Lachowski, D; Oertle, P; Matellan, C; Thorpe, SD; Ghose, R; Wang, H; Lee, DA; Plodinec, M (2020-01-25)The invasive properties of cancer cells are intimately linked to their mechanical phenotype, which can be regulated by intracellular biochemical signalling. Cell contractility, induced by mechanotransduction of a stiff ... -
GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.
Cortes, E; Sarper, M; Robinson, B; Lachowski, D; Chronopoulos, A; Thorpe, SD; Lee, DA; Del Río Hernández, AE (2019-01)The mechanical properties of the tumor microenvironment are emerging as attractive targets for the development of therapies. Tamoxifen, an agonist of the G protein-coupled estrogen receptor (GPER), is widely used to treat ... -
Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway
Chronopoulos, A; Thorpe, SD; Cortes, E; Lachowski, D; Rice, AJ; Mykuliak, VV; Rog, T; Lee, DA; Hytonen, VP; Hernandez, AEDR (2020-01-06) -
Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor
Cortes, E; Lachowski, D; Rice, A; Thorpe, SD; Robinson, B; Yeldag, G; Lee, DA; Ghemtio, L; Rombouts, K; Hernandez, AEDR (2019-04-18) -
Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival
Cortes, E; Lachowski, D; Robinson, B; Sarper, M; Teppo, JS; Thorpe, SD; Lieberthal, TJ; Iwamoto, K; Lee, DA; Okada-Hatakeyama, M (2019-01)