Browsing School of Engineering and Materials Science by Author "Bader, DL"
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3D models of chondrocytes within biomimetic scaffolds: Effects of cell deformation from loading regimens.
Di Federico, E; Bader, DL; Shelton, JC (2020-10)BACKGROUND: Mechanical conditioning has been widely used to attempt to enhance chondrocyte metabolism for the evolution of functionally competent cartilage. However, although upregulation of proteoglycans have been reported ... -
Biomechanical Conditioning Enhanced Matrix Synthesis in Nucleus Pulposus Cells Cultured in Agarose Constructs with TGFβ.
Tilwani, RK; Bader, DL; Chowdhury, TT (2012-01-05)Biomechanical signals play an important role in normal disc metabolism and pathology. For instance, nucleus pulposus (NP) cells will regulate metabolic activities and maintain a balance between the anabolic and catabolic ... -
Biomechanical influence of cartilage homeostasis in health and disease.
Bader, DL; Salter, DM; Chowdhury, TT (2011)There is an urgent demand for long term solutions to improve osteoarthritis treatments in the ageing population. There are drugs that control the pain but none that stop the progression of the disease in a safe and efficient ... -
Complex mechanical conditioning of cell-seeded agarose constructs can influence chondrocyte biosynthetic activity
DiFederico, E; Shelton, JC; Bader, DL (2017-07) -
Dynamic compression counteracts IL-1 beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs
Chowdhury, TT; Arghandawi, S; Brand, J; Akanji, OO; Bader, DL; Salter, DM; Lee, DA (2008) -
Low oxygen tension increased fibronectin fragment induced catabolic activities--response prevented with biomechanical signals.
Parker, E; Vessillier, S; Pingguan-Murphy, B; Abas, W; Bader, DL; Chowdhury, TT (2013-10-25)INTRODUCTION: The inherent low oxygen tension in normal cartilage has implications on inflammatory conditions associated with osteoarthritis (OA). Biomechanical signals will additionally contribute to changes in tissue ... -
Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model
Peake, N; Su, N; Ramachandran, M; Achan, P; Salter, DM; Bader, DL; Moyes, AJ; Hobbs, AJ; Chowdhury, TT (2013) -
Oxygen tension modulates the effects of TNF alpha in compressed chondrocytes
Tilwani, RK; Vessillier, S; Pingguan-Murphy, B; Lee, DA; Bader, DL; Chowdhury, TT (2017-01) -
The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures
Vaughan, NM; Grainger, J; Bader, DL; Knight, MM (2010-12) -
Viscoelastic Cell Mechanics and Actin Remodelling Are Dependent on the Rate of Applied Pressure
Pravincumar, P; Bader, DL; Knight, MM (2012-09-11)