Browsing School of Engineering and Materials Science by Author "Iskratsch, T"
Now showing items 1-20 of 35
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Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability
Santos, LC; Blair, DA; Kumari, S; Cammer, M; Iskratsch, T; Herbin, O; Alexandropoulos, K; Dustin, ML; Sheetz, MP (2016) -
alpha-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions
Meacci, G; Wolfenson, H; Liu, S; Stachowiak, MR; Iskratsch, T; Mathur, A; Ghassemi, S; Gauthier, N; Tabdanov, E; Lohner, J (2016-11-07) -
Announcing the call for the Special Issue on “Cardiovascular mechanobiology—a special issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology, and disease”
Swiatlowska, P; Iskratsch, T (Springer Science and Business Media LLC, 2021-05)This Commentary describes a call for submissions for the upcoming special issue focused on the state of the art of cardiovascular mechanobiology research and the newest insights into the role of mechanical forces in ... -
Calponin-3 is critical for coordinated contractility of actin stress fibers
Ciuba, K; Hawkes, W; Tojkander, S; Kogan, K; Engel, U; Iskratsch, T; Lappalainen, P (2018) -
Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions
Pandey, P; Hawkes, W; Hu, J; Megone, WV; Gautrot, J; Anilkumar, N; Zhang, M; Hirvonen, L; Cox, S; Ehler, E (2018-02-05) -
Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions (vol 44, pg 326, 2018)
Pandey, P; Hawkes, W; Hu, J; Megone, WV; Gautrot, J; Anilkumar, N; Zhang, M; Hirvonen, L; Cox, S; Ehler, E (2018-06-04) -
Cardiovascular Mechano-Epigenetics: Force-Dependent Regulation of Histone Modifications and Gene Regulation
Swiatlowska, P; Iskratsch, T (2023) -
Cardiovascular mechanobiology-a Special Issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology and disease.
Swiatlowska, P; Iskratsch, T (2021-10)There has been much progress recently in the area of cardiovascular mechanobiology and this Special Issue aims at taking stock. This editorial gives context of the main motivation for this special issue as well as a brief ... -
Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing
Di Cio, S; Iskratsch, T; Connelly, JT; Gautrot, JE (Elsevier, 2020-02)The nanotopography and nanoscale geometry of the extra-cellular matrix (ECM) are important regulators of cell adhesion, motility and fate decision. However, unlike the sensing of matrix mechanics and ECM density, the ... -
Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events
Wolfenson, H; Iskratsch, T; Sheetz, MP (2014) -
Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions
Lynch, CD; Lazar, AM; Iskratsch, T; Zhang, X; Sheetz, MP (2013-01-01) -
Factoring in the force: A novel role for eIF6
Wilson, DGS; Iskratsch, T (2022) -
FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration
Iskratsch, T; Yu, C-H; Mathur, A; Liu, S; Stevenin, V; Dwyer, J; Hone, J; Ehler, E; Sheetz, M (2013-12-09) -
Finding the weakest link - exploring integrin-mediated mechanical molecular pathways
Roca-Cusachs, P; Iskratsch, T; Sheetz, MP (2012-07-01) -
The Formin FHOD1 in Cardiomyocytes
Dwyer, J; Pluess, M; Iskratsch, T; dos Remedios, CG; Ehler, E (2014-09) -
Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
Iskratsch, T; Lange, S; Dwyer, J; Kho, AL; dos Remedios, C; Ehler, E (2010-12-13) -
Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing.
Marhuenda, E; Fabre, C; Zhang, C; Martin-Fernandez, M; Iskratsch, T; Saleh, A; Bauchet, L; Cambedouzou, J; Hugnot, J-P; Duffau, H (2021-04-24)BACKGROUND: Glioblastomas stem-like cells (GSCs) by invading the brain parenchyma, remains after resection and radiotherapy and the tumoral microenvironment become stiffer. GSC invasion is reported as stiffness sensitive ... -
Hypertensive pressure mechanosensing alone triggers lipid droplet accumulation and transdifferentiation of vascular smooth muscle cells to foam cells
Iskratsch, T; Swiatlowska, P; Tipping, W; Marhuenda, E; Severi, P; Fomin, V; Yang, Z; Xiao, Q; Graham, D; Shanahan, C (Wiley Open Access, 2023)Arterial Vascular smooth muscle cells (VSMCs) play a central role in the onset and progression of atherosclerosis. Upon exposure to pathological stimuli, they can take on alternative phenotypes that, among others, have ... -
Lem2 is essential for cardiac development by maintaining nuclear integrity
Ross, JA; Arcos-Villacis, N; Battey, E; Boogerd, C; Orellana, CA; Marhuenda, E; Swiatlowska, P; Hodzic, D; Prin, F; Mohun, T (Oxford University Press, 2023)Aims: Nuclear envelope integrity is essential for the compartmentalization of the nucleus and cytoplasm. Importantly, mutations in genes encoding nuclear envelope (NE) and associated proteins are the second highest cause ... -
Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching
Swiatlowska, P; Sit, B; Feng, Z; Marhuenda, E; Xanthis, I; Zingaro, S; Ward, M; Zhou, X; Xiao, Q; Shanahan, C (2020-12-28)Vascular smooth muscle cells (VSMCs) play a central role in the onset and progression of atherosclerosis. In pre-atherosclerotic lesions, VSMCs switch from a contractile to a synthetic phenotype and subsequently remodel ...