Hepatitis B virus infection as a neglected tropical disease.
e0005842 - ?
PLoS Negl Trop Dis
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The Global Hepatitis Health Sector Strategy is aiming for “elimination of viral hepatitis as a public health threat” by 2030 , while enhanced elimination efforts for hepatitis are also promoted under the broader remit of global Sustainable Development Goals (SDGs) . This is an enormous challenge for hepatitis B virus (HBV) given the estimated global burden of 260 million chronic carriers, of whom the majority are unaware of their infection  (Fig 1). thumbnail Download: PPT PowerPoint slide PNG larger image TIFF original image Fig 1. The hepatitis B virus (HBV) cascade. Diagrammatic representation of the total burden of HBV infection and the subsets of individuals who are diagnosed (orange), linked to care (green), engaged with care (blue), on treatment (light purple), and have suppressed viremia (dark purple). An estimate of the proportion of cases undiagnosed versus diagnosed (91% versus 9%, respectively) is based on the WHO fact sheet . The proportion who flow from each pool to the next is otherwise represented by a question mark, as these numbers are not represented by robust data. https://doi.org/10.1371/journal.pntd.0005842.g001 We here present HBV within the framework for neglected tropical diseases (NTDs)  in order to highlight the ways in which HBV meets NTD criteria and to discuss the ways in which the NTD management paradigm could be used to strengthen a unified global approach to HBV elimination . The major burden of morbidity and mortality from HBV is now borne by tropical and subtropical countries . Many African populations epitomize specific vulnerability to HBV , so we here focus particular attention on Africa, both through focus on the existing published literature and through presentation of a unique data set of opinion and experience (see S1 Supporting Information). However, the themes we represent are transferable to other low- and middle-income settings and are relevant on the global stage.
AuthorsO'Hara, GA; McNaughton, AL; Maponga, T; Jooste, P; Ocama, P; Chilengi, R; Mokaya, J; Liyayi, MI; Wachira, T; Gikungi, DM; Burbridge, L; O'Donnell, D; Akiror, CS; Sloan, D; Torimiro, J; Yindom, LM; Walton, R; Andersson, M; Marsh, K; Newton, R; Matthews, PC
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