Browsing Centre for Preventative Neurology by Subject "Parkinson's disease"
Now showing items 1-14 of 14
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Differences in the Presentation and Progression of Parkinson's Disease by Sex
(Wiley, 2020-10-01) -
Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease.
(Elsevier, 2017-12-20)SNCA missense mutations are a rare cause of autosomal dominant Parkinson's disease (PD). To date, 6 missense mutations in SNCA have been nominated as causal. Here, we assess the frequency of these 6 mutations in public ... -
Investigation of Autosomal Genetic Sex Differences in Parkinson's disease.
(2021-04-26)OBJECTIVE: Parkinson's disease (PD) is a complex neurodegenerative disorder. Males are on average ~ 1.5 times more likely to develop PD compared to females with European ancestry. Over the years genome-wide association ... -
Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson's Disease.
(2021-05-11)BACKGROUND: Epidemiological studies have reported an association between Parkinson's disease (PD) and restless legs syndrome. OBJECTIVES: We aimed to use genetic data to study whether these 2 disorders are causally linked ... -
The Motor Dysfunction Seen in Isolated REM Sleep Behavior Disorder.
(2024-03-12)BACKGROUND: Isolated Rapid Eye Movement (REM) sleep Behavior Disorder (iRBD) requires quantitative tools to detect incipient Parkinson's disease (PD). METHODS: A motor battery was designed and compared with the Movement ... -
Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms
(Wiley, 2019-04-07)Background: Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome‐wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the ... -
Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms
(Wiley, 2019-04-07)Background: Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome‐wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the ... -
Potential Protective Link Between Type I Diabetes and Parkinson's Disease Risk and Progression
(Wiley, 2023-05-06)BACKGROUND: Epidemiological studies suggested an association between Parkinson's disease (PD) and type 2 diabetes, but less is known about type 1 diabetes (T1D) and PD. OBJECTIVE: This study sought to explore the association ... -
Predicting Diagnosis of Parkinson’s disease: A Risk Algorithm based on Primary Care presentations
(Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society, 2019-02-08)BACKGROUND: Diagnosis of Parkinson's disease (PD) is typically preceded by nonspecific presentations in primary care. OBJECTIVES: The objective of this study was to develop and validate a prediction model for diagnosis ...