Browsing Centre for Preventative Neurology by Subject "GBA"
Now showing items 1-4 of 4
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Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.
(2020-01-01)Parkinson's disease is a genetically complex disorder. Multiple genes have been shown to contribute to the risk of Parkinson's disease, and currently 90 independent risk variants have been identified by genome-wide association ... -
Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms
(Wiley, 2019-04-07)Background: Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome‐wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the ... -
Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms
(Wiley, 2019-04-07)Background: Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome‐wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the ... -
Phenotypic effect of GBA1 variants in individuals with and without Parkinson's disease: The RAPSODI study
(Elsevier, 2023-11-03)BACKGROUND: Variants in the GBA1 gene cause the lysosomal storage disorder Gaucher disease (GD). They are also risk factors for Parkinson's disease (PD), and modify the expression of the PD phenotype. The penetrance of ...