Browsing Centre for Preventative Neurology by Author "Jacobs, BM"
Now showing items 1-12 of 12
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Big data, machine learning and artificial intelligence: a neurologist's guide.
Auger, SD; Jacobs, BM; Dobson, R; Marshall, CR; Noyce, AJ (2020-09-29)Modern clinical practice requires the integration and interpretation of ever-expanding volumes of clinical data. There is, therefore, an imperative to develop efficient ways to process and understand these large amounts ... -
BMI and low vitamin D are causal factors for multiple sclerosis: A Mendelian Randomization study.
Jacobs, BM; Noyce, AJ; Giovannoni, G; Dobson, R (2020-03)OBJECTIVE: To update the causal estimates for the effects of adult body mass index (BMI), childhood BMI, and vitamin D status on multiple sclerosis (MS) risk. METHODS: We used 2-sample Mendelian randomization to determine ... -
Exploring the shared genetic architecture of modifiable risk factors and related endophenotypes of Alzheimer’s disease: A genomic SEM study
Foote, IF; Jacobs, BM; Noyce, AJ; Korszun, A; Bhui, KS; Marshall, CR (2020-12-07) -
Gene-Environment Interactions for Parkinson's Disease.
Reynoso, A; Torricelli, R; Jacobs, BM; Shi, J; Aslibekyan, S; Norcliffe-Kaufmann, L; Noyce, AJ; Heilbron, K (2023-12-19)OBJECTIVE: Parkinson's disease (PD) is a neurodegenerative disorder with complex etiology. Multiple genetic and environmental factors have been associated with PD, but most PD risk remains unexplained. The aim of this study ... -
Investigation of Autosomal Genetic Sex Differences in Parkinson's disease.
Blauwendraat, C; Iwaki, H; Makarious, MB; Bandres-Ciga, S; Leonard, H; Grenn, FP; Lake, J; Krohn, L; Tan, M; Kim, JJ (2021-04-26)OBJECTIVE: Parkinson's disease (PD) is a complex neurodegenerative disorder. Males are on average ~ 1.5 times more likely to develop PD compared to females with European ancestry. Over the years genome-wide association ... -
Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank
Jacobs, BM; Belete, D; Bestwick, J; Blauwendraat, C; Bandres-Ciga, S; Heilbron, K; Dobson, R; Nalls, MA; Singleton, A; Hardy, J (BMJ, 2020-10) -
Plasma proteomic profiles of UK Biobank participants with multiple sclerosis.
Jacobs, BM; Vickaryous, N; Giovannoni, G; Proitsi, P; Waters, S; Dobson, R (Wiley Open Access, 2024-01-28)OBJECTIVE: We aimed to describe plasma protein biomarkers of multiple sclerosis risk and to explore protein biomarkers of disease severity using radiological outcome measures. METHODS: Multiple sclerosis cases and controls ... -
Polygenic risk score prediction of multiple sclerosis in individuals of South Asian ancestry
Breedon, JR; Marshall, CR; Giovannoni, G; van Heel, DA; Dobson, R; Jacobs, BM (2023) -
Remote testing of vitamin D levels across the UK MS population-A case control study.
Vickaryous, N; Jitlal, M; Jacobs, BM; Middleton, R; Chandran, S; MacDougall, NJJ; Giovannoni, G; Dobson, R (Public Library of Science, 2020-12-30)OBJECTIVE: The association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study ... -
RISK FACTORS AND PARKINSON'S DISEASE PRESENTATIONS IN PRIMARY CARE IN A DIVERSE UK POPULATION
Simonet, C; Bestwick, J; Jitlal, M; Waters, S; Ben-Joseph, A; Mar-Shall, CR; Dobson, R; Jacobs, BM; Schrag, A; Noyce, AJ (2022) -
Towards a global view of multiple sclerosis genetics
Jacobs, BM; Peter, M; Giovannoni, G; Noyce, AJ; Morris, HR; Dobson, R (2022) -
Vitamin D genetic risk scores in multiple sclerosis
Kuri, A; Vickaryous, N; Awad, A; Jacobs, BM; Dobson, R (2023)