Browsing Centre for Preventative Neurology by Title
Now showing items 91-110 of 137
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Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms
(Wiley, 2019-04-07)Background: Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome‐wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the ... -
Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms
(Wiley, 2019-04-07)Background: Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome‐wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the ... -
Phenotypic effect of GBA1 variants in individuals with and without Parkinson's disease: The RAPSODI study
(Elsevier, 2023-11-03)BACKGROUND: Variants in the GBA1 gene cause the lysosomal storage disorder Gaucher disease (GD). They are also risk factors for Parkinson's disease (PD), and modify the expression of the PD phenotype. The penetrance of ... -
Plasma proteomic profiles of UK Biobank participants with multiple sclerosis.
(Wiley Open Access, 2024-01-28)OBJECTIVE: We aimed to describe plasma protein biomarkers of multiple sclerosis risk and to explore protein biomarkers of disease severity using radiological outcome measures. METHODS: Multiple sclerosis cases and controls ... -
Potential Protective Link Between Type I Diabetes and Parkinson's Disease Risk and Progression
(Wiley, 2023-05-06)BACKGROUND: Epidemiological studies suggested an association between Parkinson's disease (PD) and type 2 diabetes, but less is known about type 1 diabetes (T1D) and PD. OBJECTIVE: This study sought to explore the association ... -
Predicting Diagnosis of Parkinson’s disease: A Risk Algorithm based on Primary Care presentations
(Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society, 2019-02-08)BACKGROUND: Diagnosis of Parkinson's disease (PD) is typically preceded by nonspecific presentations in primary care. OBJECTIVES: The objective of this study was to develop and validate a prediction model for diagnosis ... -
Primary progressive aphasia: a clinical approach
(2018-06) -
Processing of Degraded Speech in Brain Disorders
The speech we hear every day is typically “degraded” by competing sounds and the idiosyncratic vocal characteristics of individual speakers. While the comprehension of “degraded” speech is normally automatic, it depends ... -
Real-world persistence of multiple sclerosis disease-modifying therapies.
(John Wiley & Sons Ltd, 2024-04-03)BACKGROUND AND PURPOSE: Treatment persistence is the continuation of therapy over time. It reflects a combination of treatment efficacy and tolerability. We aimed to describe real-world rates of persistence on disease-modifying ...