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    Protocol and quality assurance for carotid imaging in 100,000 participants of UK Biobank: development and assessment. 
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    • Protocol and quality assurance for carotid imaging in 100,000 participants of UK Biobank: development and assessment.
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    • Protocol and quality assurance for carotid imaging in 100,000 participants of UK Biobank: development and assessment.
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    Protocol and quality assurance for carotid imaging in 100,000 participants of UK Biobank: development and assessment.

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    Accepted version (4.551Mb)
    Volume
    24
    Pagination
    1799 - 1806
    DOI
    10.1177/2047487317732273
    Journal
    Eur J Prev Cardiol
    Issue
    17
    Metadata
    Show full item record
    Abstract
    Background Ultrasound imaging is able to quantify carotid arterial wall structure for the assessment of cerebral and cardiovascular disease risks. We describe a protocol and quality assurance process to enable carotid imaging at large scale that has been developed for the UK Biobank Imaging Enhancement Study of 100,000 individuals. Design An imaging protocol was developed to allow measurement of carotid intima-media thickness from the far wall of both common carotid arteries. Six quality assurance criteria were defined and a web-based interface (Intelligent Ultrasound) was developed to facilitate rapid assessment of images against each criterion. Results and conclusions Excellent inter and intra-observer agreements were obtained for image quality evaluations on a test dataset from 100 individuals. The image quality criteria then were applied in the UK Biobank Imaging Enhancement Study. Data from 2560 participants were evaluated. Feedback of results to the imaging team led to improvement in quality assurance, with quality assurance failures falling from 16.2% in the first two-month period examined to 6.4% in the last. Eighty per cent had all carotid intima-media thickness images graded as of acceptable quality, with at least one image acceptable for 98% of participants. Carotid intima-media thickness measures showed expected associations with increasing age and gender. Carotid imaging can be performed consistently, with semi-automated quality assurance of all scans, in a limited timeframe within a large scale multimodality imaging assessment. Routine feedback of quality control metrics to operators can improve the quality of the data collection.
    Authors
    Coffey, S; Lewandowski, AJ; Garratt, S; Meijer, R; Lynum, S; Bedi, R; Paterson, J; Yaqub, M; Noble, JA; Neubauer, S
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/31331
    Collections
    • NIHR Advanced Imaging [345]
    Language
    eng
    Licence information
    Sean Coffey et al., Protocol and quality assurance for carotid imaging in 100,000 participants of UK Biobank: development and assessment., European Journal of Preventive Cardiology Vol. 24(17) pp. 1799-1806. Copyright © 2017 The European Society of Cardiology. Reprinted by permission of SAGE Publications.
    Copyright statements
    © The European Society of Cardiology 2017

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