dc.contributor.author | Darshan, GH | en_US |
dc.contributor.author | Kong, D | en_US |
dc.contributor.author | Gautrot, J | en_US |
dc.contributor.author | Vootla, S | en_US |
dc.date.accessioned | 2017-12-15T10:50:05Z | |
dc.date.available | 2017-08-10 | en_US |
dc.date.issued | 2017-09-04 | en_US |
dc.date.submitted | 2017-12-07T09:38:09.406Z | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/30448 | |
dc.description.abstract | In the field of plastic reconstructive surgery, development of new innovative matrices for skin repair is in demand. The ideal biomaterial should promote attachment, proliferation and growth of cells. Additionally, it should degrade in an appropriate time period without releasing harmful substances, not exerting a pathological immune response. The materials used should display optimized mechanical properties to sustain cell growth and limit scaffold contraction. Wound healing is a biological process directed towards restoration of tissue that has suffered an injury. An important phase of wound healing is the generation of a basal epithelium wholly replacing the epidermis of the wound. Wild silk from Antheraea mylitta meets these demands to a large extent. To evaluate the effects of the treatment, Antheraea mylitta and Bombyx mori samples were characterized by SEM-EDX, FT-IR, XRD and TGA-DSC techniques. Preliminary cell growth behavior was carried out by culturing epidermal cells and proliferation was quantified via viability assay. Moreover, Antheraea mylitta possesses excellent cell-adhesive capability, effectively promoting cell attachment and proliferation. Antheraea mylitta serves as a delivery vehicle for cells. With all these unique features, it is expected that Antheraea mylitta mat will have wide utility in the areas of tissue engineering and regenerative medicine. | en_US |
dc.description.sponsorship | Prof. Shyamkumar Vootla and Dr. Julien Gautrot thanks to Department of Science and Technology (DST),
New Delhi. India and United Kingdom India Education and Research Initiative (UKIERI), British Council,
United Kingdom, for funding of this project (DST/INT/UK/P-52). Tis work was supported by Commonwealth
Academic Fellowship awarded to Prof. Shyamkumar Vootla by the Commonwealth Association of Universities,
United Kingdom. | en_US |
dc.format.extent | 10344 - ? | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Sci Rep | en_US |
dc.rights | Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.subject | Animals | en_US |
dc.subject | Biocompatible Materials | en_US |
dc.subject | Chemical Phenomena | en_US |
dc.subject | Fluorescent Antibody Technique | en_US |
dc.subject | Humans | en_US |
dc.subject | Keratinocytes | en_US |
dc.subject | Moths | en_US |
dc.subject | Silk | en_US |
dc.subject | Spectrum Analysis | en_US |
dc.subject | Surface Properties | en_US |
dc.subject | Thermogravimetry | en_US |
dc.subject | Tissue Scaffolds | en_US |
dc.subject | Wound Healing | en_US |
dc.title | Physico-chemical characterization of Antheraea mylitta silk mats for wound healing applications. | en_US |
dc.type | Article | |
dc.rights.holder | © 2017 The Author(s). | |
dc.identifier.doi | 10.1038/s41598-017-10531-7 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28871135 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 7 | en_US |
dcterms.dateAccepted | 2017-08-10 | en_US |