Selective Tsuji–Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles
14490 - 14493
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The 4,5-dihydropyrazole motif has drawn considerable attention over the years as it was shown to exhibit a plethora of biological and pharmacological properties, including anticancer, antibacterial, antifungal, antiviral, and anti-inflammatory properties. As such, it has been the target of a number of methods and drug discovery programs. We report here a straightforward and highly selective approach featuring a key palladium-catalysed Tsuji–Trost type C-allylation and subsequent intramolecular 1,4-addition of hydrazones.
AuthorsEl Mamouni, EH; Cattoen, M; Cordier, M; Cossy, J; Arseniyadis, S; Ilitki, H; El Kaïm, L
- College Publications