Browsing Psychology by Author "van der Flier, FE"
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Perseveration and Shifting in Obsessive-Compulsive Disorder as a Function of Uncertainty, Punishment, and Serotonergic Medication
Apergis-Schoute, AM; van der Flier, FE; Ip, SHY; Kanen, JW; Vaghi, MM; Fineberg, NA; Sahakian, BJ; Cardinal, RN; Robbins, TW (Elsevier, 2023-01-01)Background: The nature of cognitive flexibility deficits in obsessive-compulsive disorder (OCD), which historically have been tested with probabilistic reversal learning tasks, remains elusive. Here, a novel deterministic ... -
Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans.
Kanen, JW; Apergis-Schoute, AM; Yellowlees, R; Arntz, FE; van der Flier, FE; Price, A; Cardinal, RN; Christmas, DM; Clark, L; Sahakian, BJ (Springer Nature, 2021-08-24)Serotonin is involved in updating responses to changing environmental circumstances. Optimising behaviour to maximise reward and minimise punishment may require shifting strategies upon encountering new situations. Likewise, ...