Browsing Psychology by Author "Robbins, TW"
Now showing items 1-4 of 4
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Atypical action updating in a dynamic environment associated with adolescent obsessive-compulsive disorder.
Marzuki, AA; Vaghi, MM; Conway-Morris, A; Kaser, M; Sule, A; Apergis-Schoute, A; Sahakian, BJ; Robbins, TW (Wiley, 2022-05-10)BACKGROUND: Computational research had determined that adults with obsessive-compulsive disorder (OCD) display heightened action updating in response to noise in the environment and neglect metacognitive information (such ... -
Perseveration and Shifting in Obsessive-Compulsive Disorder as a Function of Uncertainty, Punishment, and Serotonergic Medication
Apergis-Schoute, AM; van der Flier, FE; Ip, SHY; Kanen, JW; Vaghi, MM; Fineberg, NA; Sahakian, BJ; Cardinal, RN; Robbins, TW (Elsevier, 2023-01-01)Background: The nature of cognitive flexibility deficits in obsessive-compulsive disorder (OCD), which historically have been tested with probabilistic reversal learning tasks, remains elusive. Here, a novel deterministic ... -
Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans.
Kanen, JW; Apergis-Schoute, AM; Yellowlees, R; Arntz, FE; van der Flier, FE; Price, A; Cardinal, RN; Christmas, DM; Clark, L; Sahakian, BJ (Springer Nature, 2021-08-24)Serotonin is involved in updating responses to changing environmental circumstances. Optimising behaviour to maximise reward and minimise punishment may require shifting strategies upon encountering new situations. Likewise, ... -
Threat reversal learning and avoidance habits in generalised anxiety disorder.
Roberts, C; Apergis-Schoute, AM; Bruhl, A; Nowak, M; Baldwin, DS; Sahakian, BJ; Robbins, TW (2022-05-31)Avoidance and heightened responses to perceived threats are key features of anxiety disorders. These disorders are characterised by inflexibility in dynamically updating behavioural and physiological responses to aversively ...