Browsing Psychology by Author "Busch-Nentwich, EM"
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Conserved roles for Hnf4 family transcription factors in zebrafish development and intestinal function.
Heppert, JK; Lickwar, CR; Tillman, MC; Davis, BR; Davison, JM; Lu, H-Y; Chen, W; Busch-Nentwich, EM; Corcoran, DL; Rawls, JF (2022-11-30)Transcription factors play important roles in the development of the intestinal epithelium and its ability to respond to endocrine, nutritional, and microbial signals. Hepatocyte nuclear factor 4 family nuclear receptors ... -
Gaucher disease protects against tuberculosis.
Fan, J; Hale, VL; Lelieveld, LT; Whitworth, LJ; Busch-Nentwich, EM; Troll, M; Edelstein, PH; Cox, TM; Roca, FJ; Aerts, JMFG (2023-02-14)Biallelic mutations in the glucocerebrosidase (GBA1) gene cause Gaucher disease, characterized by lysosomal accumulation of glucosylceramide and glucosylsphingosine in macrophages. Gaucher and other lysosomal diseases occur ... -
P38 Mediates Tumor Suppression through Reduced Autophagy and Actin Cytoskeleton Changes in NRAS-Mutant Melanoma.
Banik, I; Ghosh, A; Beebe, E; Burja, B; Bertoncelj, MF; Dooley, CM; Markkanen, E; Dummer, R; Busch-Nentwich, EM; Levesque, MP (2023-01-31)Hotspot mutations in the NRAS gene are causative genetic events associated with the development of melanoma. Currently, there are no FDA-approved drugs directly targeting NRAS mutations. Previously, we showed that p38 acts ... -
Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri.
Torraca, V; White, RJ; Sealy, IM; Mazon-Moya, M; Duggan, G; Willis, AR; Busch-Nentwich, EM; Mostowy, S (Disease Models & Mechanisms, 2024-01-26)Shigella flexneri is a human-adapted pathovar of Escherichia coli that can invade the intestinal epithelium, causing inflammation and bacillary dysentery. Although an important human pathogen, the host response to S. ...