Browsing School of Biological and Chemical Sciences by Subject "Kidney Neoplasms"
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A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation.
(Springer Nature, 2023-08-01)SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss and depletion ...