Browsing School of Biological and Chemical Sciences by Subject "2 Aetiology"
Now showing items 1-13 of 13
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Copper(II) Can Kinetically Trap Arctic and Italian Amyloid‑β40 as Toxic Oligomers, Mimicking Cu(II) Binding to Wild-Type Amyloid‑β42: Implications for Familial Alzheimer’s Disease
(American Chemical Society (ACS), 2024-02-06)The self-association of amyloid-β (Aβ) peptide into neurotoxic oligomers is believed to be central to Alzheimer’s disease (AD). Copper is known to impact Aβ assembly, while disrupted copper homeostasis impacts phenotype ... -
Cyto-nuclear incompatibilities across a bluebell hybrid zone in northern Spain do not prevent genome-wide introgression of neutral markers
(Oxford University Press (OUP), 2022-01-01) -
Glycoprotein Acetyls Is a Novel Biomarker Predicting Cardiovascular Complications in Rheumatoid Arthritis
(MDPI, 2024)The relationship between rheumatoid arthritis (RA) and early onset atherosclerosis is well depicted, each with an important inflammatory component. Glycoprotein acetyls (GlycA), a novel biomarker of inflammation, may play ... -
Identification of the first structurally validated covalent ligands of the small GTPase RAB27A
(Royal Society of Chemistry (RSC), 2022-02-23) -
Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models
(Springer Nature, 2024-02-19)RBFOX1 is a highly pleiotropic gene that contributes to several psychiatric and neurodevelopmental disorders. Both rare and common variants in RBFOX1 have been associated with several psychiatric conditions, but the ... -
VP.81 In vivo modulation of novel genetic modifiers for LAMA2-RD
(Elsevier, 2022-10)