Browsing School of Biological and Chemical Sciences by Author "O'Connell, MA"
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Peptide-Directed Binding for the Discovery of Modulators of alpha-Helix Mediated Protein Protein Interactions: Proof-of-Concept Studies with the Apoptosis Regulator Mcl-1
Beekman, AM; O'Connell, MA; Howell, LA (2017-08-21) -
Peptide‐Directed Binding for the Discovery of Modulators of α‐Helix‐Mediated Protein–Protein Interactions: Proof‐of‐Concept Studies with the Apoptosis Regulator Mcl‐1
Beekman, AM; O'Connell, MA; Howell, LA (Published by Wiley-VCH Verlag GmbH & Co. KGaA., 2017-08-21)Targeting PPIs with small molecules can be challenging owing to large, hydrophobic binding surfaces. Herein, we describe a strategy that exploits selective α‐helical PPIs, transferring these characteristics to small ...