dc.description.abstract | The aim of the present study is to create a computational model of the ureteral
system that accurately mimics its dynamic functionality. This model will be able
to replicate the peristaltic movement of the ureter for a variety of physiological
conditions. The objective of this research was met using our in-house fluid solid
interaction model, known as coupled Cgles-Y-code in which the moving boundaries
between the solid and fluid domain were replicated using a novel immersed
boundary method. First, a comprehensive literature review on ureteral physiology
was conducted with a focus on the anatomy of the ureter and theories
behind mechanisms of ureteral peristaltic function in various physiological and
pathological conditions. Next, the nonlinear tensile properties of the ureteral
wall were integrated into the Y-code using the equivalent strain method and the
resulting model was compared with a model with linear tensile properties. It was
shown that the implementation of nonlinear tensile properties was more accurate
and more closely matched the behaviour of the native ureteral wall. Next,
the development of more anatomically accurate ureter model geometry was presented
along with a variety of approaches to optimise the mesh resolution for
this complex model. A new algorithm was then developed in order to model
the Intra-Abdominal Pressure (IAP) into the Y-code. Next, two separate contraction
models, constant radial and time-window-frame, were introduced. It was
observed that a use of the time-window-frame contraction model coupled with the
IAP algorithm exhibited a better agreement with the existing clinical data than
the constant radial contraction model. Finally, a comprehensive study was conducted
on the urodynamic responses when different pathological conditions are
modelled. The results from using a linear tensile model, replicating an unhealthy
condition, showed a high level of shear stress around the contraction lumen and
a higher urine velocity in vicinity of the contraction region. In another scenario,
a highly depressed amplitude of peristalsis, known to be a consequence of taking
vasodilators, was simulated. It was shown that an inefficient contraction can
increase the possibility of continuous reflux during the propagation of peristalsis. | en_US |